Previous Statin Use Is Not Associated With an Increased Prevalence or Degree of Gradient-Echo Lesions in Patients With Acute Ischemic Stroke or Transient Ischemic Attack

Jason S DAY; Bruno A POLICENI; Wendy R. K SMOKER; Mircea C DOBRE; Ying Zhang; Enrique C LEIRA; Patricia H DAVIS; Sherman CHEN; Heena OLALDE; Harold P ADAMS

doi:10.1161/STROKEAHA.110.594101

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Previous Statin Use Is Not Associated With an Increased Prevalence or Degree of Gradient-Echo Lesions in Patients With Acute Ischemic Stroke or Transient Ischemic Attack

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Previous Statin Use Is Not Associated With an Increased Prevalence or Degree of Gradient-Echo Lesions in Patients With Acute Ischemic Stroke or Transient Ischemic Attack

Jason S DAY, Bruno A POLICENI, Wendy R. K SMOKER, Mircea C DOBRE, Ying Zhang, Enrique C LEIRA, Patricia H DAVIS, Sherman CHEN, Heena OLALDE and Harold P ADAMS

Stroke (1970), Vol.42(2), pp.354-358

2011

DOI: 10.1161/STROKEAHA.110.594101

PMID: 21164134

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Abstract

Background and Purpose— Microhemorrhages on gradient-echo T2*-weighted MRI sequences are often found in patients with cerebrovascular disease and are related to intracerebral hemorrhage. Because statin therapy is associated with increased risk of intracerebral hemorrhage, we investigated whether statin use was also associated with microhemorrhages in patients with acute ischemic stroke or transient ischemic attack. Methods— We performed a retrospective analysis on prospectively collected data from a stroke registry containing patients with acute ischemic stroke or transient ischemic attack. The primary and secondary outcome variables were the prevalence and degree of microhemorrhages as detected on gradient-echo MRI sequences and categorized as mild (1–2), moderate (3–10), or severe (>10). The location of the microhemorrhages was noted and rated by 2 neuroradiologists. Previous use of statins and other covariates were assessed as potential predictors. Results— Three hundred forty-nine patients were admitted from June 2008 to July 2009, and 300 of which were analyzed. Microhemorrhages were detected in 70 subjects (23%); 35 had only lobar lesions, 16 had only deep lesions, and 19 had both lobar and deep lesions. On univariate and multivariate analysis, statin therapy was not associated with the prevalence (OR, 0.73; 95% CI, 0.36–1.51; P=0.40) or degree of microhemorrhages modeled for lesser severity (OR, 2.31; 95% CI, 0.61–8.75; P=0.22). Conclusions— Previous statin therapy was not associated with the prevalence or degree of microhemorrhages in patients with acute ischemic stroke or transient ischemic attack. The association between statins and intracerebral hemorrhage does not appear to be mediated through microhemorrhages.

Neurology

Biological and medical sciences

Vascular diseases and vascular malformations of the nervous system

Medical sciences

Blood. Blood coagulation. Reticuloendothelial system

Pharmacology. Drug treatments

Details

Title: Subtitle: Previous Statin Use Is Not Associated With an Increased Prevalence or Degree of Gradient-Echo Lesions in Patients With Acute Ischemic Stroke or Transient Ischemic Attack
Creators: Jason S DAY - Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States
Bruno A POLICENI - Department of Radiology, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States
Wendy R. K SMOKER - Department of Radiology, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States
Mircea C DOBRE - Department of Radiology, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States
Ying Zhang - University of Iowa College of Public Health, Iowa City, Iowa, United States
Enrique C LEIRA - Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States
Patricia H DAVIS - Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States
Sherman CHEN - Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States
Heena OLALDE - Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States
Harold P ADAMS - Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States
Resource Type: Journal article
Publication Details: Stroke (1970), Vol.42(2), pp.354-358
DOI: 10.1161/STROKEAHA.110.594101
PMID: 21164134
NLM abbreviation: Stroke
ISSN: 0039-2499
eISSN: 1524-4628
Publisher: Lippincott Williams & Wilkins; Hagerstown, MD
Language: English
Date published: 2011
Academic Unit: Neurology; Radiology; Oral Pathology, Radiology and Medicine; Epidemiology; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
Record Identifier: 9984020719002771

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