Primary Biliary Cholangitis, Liver Transplantation, and Hepatocellular Carcinoma: A Mini-review

Badi Rawashdeh; Allison Couillard; Aasem Rawshdeh; Hassan Aziz; James Esteban; Motaz Selim

doi:10.14218/GE.2022.00016

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Primary Biliary Cholangitis, Liver Transplantation, and Hepatocellular Carcinoma: A Mini-review

Journal article

Open access

Peer reviewed

Primary Biliary Cholangitis, Liver Transplantation, and Hepatocellular Carcinoma: A Mini-review

Badi Rawashdeh, Allison Couillard, Aasem Rawshdeh, Hassan Aziz, James Esteban and Motaz Selim

Gene expression, Vol.21(2), pp.34-40

12/01/2022

DOI: 10.14218/GE.2022.00016

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Abstract

Primary biliary cholangitis (PBC) is an organ-specific chronic autoimmune disease characterized by T-lymphocyte mediated destruction of intrahepatic biliary epithelial cells due to a combination of genetic and possible environmental factors. PBC progresses to hepatic fibrosis and cirrhosis, with the potential of developing hepatocellular carcinoma (HCC) if left untreated. PBC is more common in middle-aged women. It is diagnosed in patients with elevated liver enzymes and the serological hallmark of antimitochondrial antibody (AMA). Early diagnosis and treatment are crucial in improving survival and preventing long-term complications of liver disease. Ursodeoxycholic acid (UDCA) is first-line treatment for PBC. Obeticholic acid (OCA) and fibrates, in combination with UDCA or as monotherapy, may be given to PBC patients with partial or no UDCA response. Liver transplantation has thus been indicated in patients with decompensated cirrhosis or unresectable HCC.

Asymptomatic

Autoimmune diseases

Cholangitis

Cirrhosis

Environmental factors

Epidemiology

Epithelial cells

Epithelium

Esophagus

Females

Fibrosis

Gender

Hepatocellular carcinoma

Hormone replacement therapy

Hypertension

Immunoglobulins

Liver

Liver cirrhosis

Liver diseases

Liver transplantation

Lymphocytes

Lymphocytes T

Males

Medical prognosis

Middle age

Mortality

Natural history

Pathogenesis

Population

Pruritus

Transplantation

Ursodeoxycholic acid

Details

Title: Subtitle: Primary Biliary Cholangitis, Liver Transplantation, and Hepatocellular Carcinoma: A Mini-review
Creators: Badi Rawashdeh - NHS Blood and Transplant
Allison Couillard - NHS Blood and Transplant
Aasem Rawshdeh
Hassan Aziz - NHS Blood and Transplant
James Esteban
Motaz Selim - NHS Blood and Transplant
Resource Type: Journal article
Publication Details: Gene expression, Vol.21(2), pp.34-40
Publisher: Xia & He Publishing
DOI: 10.14218/GE.2022.00016
ISSN: 1052-2166
eISSN: 1555-3884
Language: English
Date published: 12/01/2022
Academic Unit: Surgery
Record Identifier: 9984701645802771

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