Journal article
Primary Cutaneous Large B-Cell Lymphoma Shows Activation of Nuclear Factor Kappa B and Low Incidence of Epstein-Barr Virus
The American journal of dermatopathology, Vol.32(5), pp.439-441
2010
DOI: 10.1097/DAD.0b013e3181c1195b
PMID: 20571344
Abstract
Primary cutaneous lymphomas are defined as lymphomas, which are present in the skin without evidence of extracutaneous disease at the time of diagnosis. Primary cutaneous large B-cell lymphoma (PCLBCL) is a subtype of primary cutaneous B-cell lymphoma with a female predominance, occurring in elderly patients and known to have unfavorable prognosis. We evaluated 10 cases of PCLBCL in immunocompetent patients between 2005 and 2008. A panel of immuoperoxidase stains; CD3, CD10, CD20, BCL2, BCL6, and MUM1 were performed on all cases. Nuclear factor kappa B (NF-κB) pathway activation was evaluated using an immunostain for P65. The presence of Epstein-Barr virus (EBV) was assessed using Epstein-Barr virus encoded RNA (EBER) in situ hybridization probe. All cases were CD20 positive and CD3 negative. CD10, BCL6, BCL2, and MUM1 were positive in 4/10 (40%), 6/10 (60%), 7/10 (70%), and 7/10 (70%) cases, respectively. NF-κB activation was detected in 7/10 (70%) cases. One (10%) case was positive for EBV by in situ hybridization. Interestingly, the EBV positive case was also positive for MUM1 and negative for CD10, indicating an activated immunophenotype. In conclusion, majority of PCLBCL shows activation of NF-κB pathway with a low incidence of EBV.
Details
- Title: Subtitle
- Primary Cutaneous Large B-Cell Lymphoma Shows Activation of Nuclear Factor Kappa B and Low Incidence of Epstein-Barr Virus
- Creators
- Sharathkumar BHAGAVATHI - Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN, United StatesA. M BLENC - Department of Pathology, William Beaumont Hospital, Royal Oak, MI, United StatesM AMIN - Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN, United StatesV. D NIKITIN - Department of Pathology, William Beaumont Hospital, Royal Oak, MI, United StatesM. C PATEL - Department of Pathology, William Beaumont Hospital, Royal Oak, MI, United StatesS WARREN - Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN, United StatesR. K MALHOTRA - Department of Pathology, William Beaumont Hospital, Royal Oak, MI, United States
- Resource Type
- Journal article
- Publication Details
- The American journal of dermatopathology, Vol.32(5), pp.439-441
- Publisher
- Lippincott Williams & Wilkins; Hagerstown, MD
- DOI
- 10.1097/DAD.0b013e3181c1195b
- PMID
- 20571344
- ISSN
- 0193-1091
- eISSN
- 1533-0311
- Language
- English
- Date published
- 2010
- Academic Unit
- Pathology
- Record Identifier
- 9984046802102771
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