Journal article
Primary Laryngectomy Versus Salvage Laryngectomy: A Comparison of Outcomes in the Chemoradiation Era
The Laryngoscope, Vol.130(9), pp.2179-2185
09/2020
DOI: 10.1002/lary.28343
PMID: 31654445
Abstract
Objective
To compare primary total laryngectomy (TL) versus salvage TL and analyze the functional outcomes, complications, recurrence rates, and survival.
Study Design
Case series with chart review.
Setting
Tertiary care center.
Subjects and Methods
Fifteen‐year retrospective analysis of 208 patients with laryngeal squamous cell carcinoma treated by TL was completed. Outcome measures included survival, swallowing rehabilitation, speech rehabilitation, complications, and assessment of comorbidity. Survival estimates were analyzed with Kaplan‐Meier method, and regression analysis utilized the Cox proportional hazards model.
Results
Alaryngeal speech was not significantly different between primary TL and salvage TL, 68% versus 82% (P = 0.14). Comparing primary and salvage TL, the perioperative complication rate was 33% versus 48% (P = 0.036). Thirty‐six percent of primary TL patients had recurrence compared to 26% of salvage patients. Five‐year overall survival rates between primary TL and salvage TL were not significantly different (P = 0.68). Comorbidity was an independent predictor of survival.
Conclusions
Development of a functional voice was not significantly different between salvage and primary TL patients, with a majority achieving alaryngeal speech. Perioperative complications were more prevalent in the salvage TL group. Recurrence and survival are significantly associated with comorbidity status.
Level of Evidence
4 Laryngoscope, 130:2179–2185, 2020
Details
- Title: Subtitle
- Primary Laryngectomy Versus Salvage Laryngectomy: A Comparison of Outcomes in the Chemoradiation Era
- Creators
- Christopher Blake Sullivan - University of Iowa Hospitals and ClinicsKatharine L. Ostedgaard - University of California, DavisZaid Al‐Qurayshi - University of Iowa Hospitals and ClinicsNitin A. Pagedar - University of IowaSteven M. Sperry - Aurora St. Luke's Medical Center
- Resource Type
- Journal article
- Publication Details
- The Laryngoscope, Vol.130(9), pp.2179-2185
- Publisher
- John Wiley & Sons, Inc
- DOI
- 10.1002/lary.28343
- PMID
- 31654445
- ISSN
- 0023-852X
- eISSN
- 1531-4995
- Number of pages
- 7
- Language
- English
- Date published
- 09/2020
- Academic Unit
- Otolaryngology
- Record Identifier
- 9984311441002771
Metrics
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