Journal article
Primary Sarcomatoid (Spindle-Cell) Diffuse Large B-Cell Lymphoma of the Uterine Cervix in a Young Adult: A Case Report
International journal of gynecological pathology
04/21/2026
DOI: 10.1097/PGP.0000000000001166
PMID: 42011749
Abstract
Primary diffuse large B-cell lymphoma (DLBCL) of the uterine cervix is an exceptionally rare extranodal malignancy. A sarcomatoid (spindle-cell) pattern of diffuse large B-cell lymphoma (DLBCL) is even more unusual and closely mimics mesenchymal or sarcomatoid epithelial tumors. We report a young woman with long-standing pelvic pain and abnormal bleeding whose cervix appeared friable and retracted, prompting biopsy. Histology showed DLBCL with sarcomatoid morphology. FISH demonstrated copy-number gains of MYC (56%) and IgH (59%) without rearrangements. PET-CT revealed an intensely FDG-avid cervical mass and a moderately avid right inferior thyroid nodule; fine-needle aspiration of the thyroid nodule was suspicious for follicular neoplasm (Bethesda IV). She began chemotherapy. This case highlights the diagnostic pitfalls of spindle morphology in cervical masses, underscores the importance of tissue confirmation of PET incidentalomas to avoid overstaging, and illustrates organ-preserving therapy in a young adult.
Details
- Title: Subtitle
- Primary Sarcomatoid (Spindle-Cell) Diffuse Large B-Cell Lymphoma of the Uterine Cervix in a Young Adult: A Case Report
- Creators
- Mohamed Eletrebi - University of IowaMostafa Abdelraheem - University of IowaSergei Syrbu - Departments of Pathology
- Resource Type
- Journal article
- Publication Details
- International journal of gynecological pathology
- DOI
- 10.1097/PGP.0000000000001166
- PMID
- 42011749
- NLM abbreviation
- Int J Gynecol Pathol
- ISSN
- 1538-7151
- eISSN
- 1538-7151
- Publisher
- Lippincott Williams & Wilkins
- Language
- English
- Electronic publication date
- 04/21/2026
- Academic Unit
- Pathology
- Record Identifier
- 9985155642702771
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