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Primary and secondary immune responses to Listeria monocytogenes
Journal article   Peer reviewed

Primary and secondary immune responses to Listeria monocytogenes

John T Harty, Laurel L Lenz and Michael J Bevan
Current opinion in immunology, Vol.8(4), pp.526-530
1996
DOI: 10.1016/S0952-7915(96)80041-0
PMCID: PMC2784914
PMID: 8794012

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Abstract

Recent studies have revealed the complexity of cytokine and cellular interactions required for resistance to primary Listeria monocytogenes infection and have illustrated that resistance to secondary infection may occur through multiple pathways. Analyses of Listeria epitope generation and the specificity of protective CD8 + T cells have suggested that future research should focus on secreted protein antigens in specific resistance to infection and have increased our understanding of Listeria antigens presented by MHC class I-b molecules.
LCMV lymphocytic choriomeningitis virus LLO listeriolysin IFN interferon IL interleukin TCR T-cell receptor LM Listeria monocytogenes NK natural killer TNF tumor necrosis factor SCID severe combined immunodeficiency

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