Primary gastric T cell lymphoma mimicking marginal zone B cell lymphoma of mucosa-associated lymphoid tissue

Danniele Holanda; Merry Y Zhao; Aaron P Rapoport; Michael Garofalo; Qing Chen; X. Frank Zhao

doi:10.1007/s12308-008-0006-8

Back

Primary gastric T cell lymphoma mimicking marginal zone B cell lymphoma of mucosa-associated lymphoid tissue

Journal article

Open access

Primary gastric T cell lymphoma mimicking marginal zone B cell lymphoma of mucosa-associated lymphoid tissue

Danniele Holanda, Merry Y Zhao, Aaron P Rapoport, Michael Garofalo, Qing Chen and X. Frank Zhao

Journal of hematopathology, Vol.1(1), pp.29-35

07/2008

DOI: 10.1007/s12308-008-0006-8

PMCID: PMC2712325

PMID: 19669202

Files and links (1)

url

https://doi.org/10.1007/s12308-008-0006-8View

Published (Version of record) Open Access

Abstract

Primary gastric T cell lymphoma is rare and mostly of large cell type. In this paper, we present a case of gastric T cell lymphoma morphologically similar to the gastric marginal zone B cell lymphoma of mucosa-associated lymphoid tissue (MALT). Morphologically, the cells are small with abundant clear cytoplasm. Lymphoepithelial lesions are readily identified with diffuse destruction of gastric glands. Immunohistochemically, the neoplastic cells are CD3+/CD4+/CD8−/Granzyme B−. Molecular studies revealed monoclonal T cell receptor γ gene rearrangement. Clinically, the patient responded initially to four cycles of R-CHOP, but then progressed. Because peripheral T cell lymphoma is usually associated with a poor prognosis, whereas marginal zone B cell lymphoma is an indolent lymphoproliferative disorder, this morphologic mimicry should be recognized and completely investigated when atypical small lymphoid infiltrates with lymphoepithelial lesions are encountered in the stomach.

H. pylori

HTLV-1

Primary gastric T cell lymphoma

Case Report

MALT

Details

Title: Subtitle: Primary gastric T cell lymphoma mimicking marginal zone B cell lymphoma of mucosa-associated lymphoid tissue
Creators: Danniele Holanda - Department of Pathology, School of Medicine, University of Maryland, Baltimore, 22 South Greene Street, Room NBW78, Baltimore, MD 21201 USA
Merry Y Zhao - Department of Pathology, School of Medicine, University of Maryland, Baltimore, 22 South Greene Street, Room NBW78, Baltimore, MD 21201 USA
Aaron P Rapoport - Department of Medicine, School of Medicine, University of Maryland, Baltimore, Baltimore, MD 21201 USA
Michael Garofalo - Department of Radiation Oncology, School of Medicine, University of Maryland, Baltimore, Baltimore, MD 21201 USA
Qing Chen - Department of Pathology, School of Medicine, University of Maryland, Baltimore, 22 South Greene Street, Room NBW78, Baltimore, MD 21201 USA
X. Frank Zhao - Department of Pathology, School of Medicine, University of Maryland, Baltimore, 22 South Greene Street, Room NBW78, Baltimore, MD 21201 USA
Resource Type: Journal article
Publication Details: Journal of hematopathology, Vol.1(1), pp.29-35
DOI: 10.1007/s12308-008-0006-8
PMID: 19669202
PMCID: PMC2712325
NLM abbreviation: J Hematop
ISSN: 1868-9256
eISSN: 1865-5785
Publisher: Springer-Verlag; Berlin/Heidelberg
Language: English
Date published: 07/2008
Academic Unit: Pathology; Internal Medicine
Record Identifier: 9984047646902771

Metrics

9 Record Views