Primary intracranial germ cell tumors: clinicopathologic review of 32 cases

K L Salzman; A M Rojiani; J Buatti; R G Quisling; R B Marcus Jr; B L Maria; J P Mickle; A Kedar

doi:10.1080/15513819709168597

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Journal article

Primary intracranial germ cell tumors: clinicopathologic review of 32 cases

K L Salzman, A M Rojiani, J Buatti, R G Quisling, R B Marcus Jr, B L Maria, J P Mickle and A Kedar

Pediatric pathology & laboratory medicine, Vol.17(5), pp.713-728

09/1997

DOI: 10.1080/15513819709168597

PMID: 9267886

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Abstract

Primary intracranial germ cell neoplasms are rare tumors and constitute a heterogeneous group. We have reviewed 32 cases, over a 21-year period, from the University of Florida. The cases include 22 germinomas, 6 mixed germ cell tumors, and 4 teratomas. The clinical presentations in these cases were more closely related to the location of the tumor, that is, pineal or suprasellar, rather than the histologic subtype. Neuroimaging evaluation was useful in distinguishing between germinomas, teratomas, and other mixed germ cell tumors (MGCTs), primarily by evaluation of cystic versus solid lesions (teratoma versus germinoma), contents of cysts (teratoma versus MGCT), and infiltrative nature of the tumors (MGCT), although cytologic-histopathologic confirmation remains necessary. Germinomas responded favorably to radiation therapy with survival periods of over 16 years; MGCTs were treated with combination chemotherapy and radiation, with a markedly poorer prognosis. This study underlines the critical significance of histopathologic evaluation of the tumor in determining therapeutic interventions as well as prognosis.

Magnetic Resonance Imaging

Brain Neoplasms - diagnostic imaging

Humans

Brain Neoplasms - pathology

Child, Preschool

Infant

Male

Tomography, X-Ray Computed

Adult

Female

Retrospective Studies

Teratoma - therapy

Brain Neoplasms - mortality

Chemotherapy, Adjuvant

Germinoma - therapy

Radiotherapy, Adjuvant

Child

Infant, Newborn

Germinoma - mortality

Germinoma - diagnostic imaging

Survival Rate

Teratoma - diagnostic imaging

Teratoma - mortality

Teratoma - pathology

Germinoma - pathology

Adolescent

Brain Neoplasms - therapy

Details

Title: Subtitle: Primary intracranial germ cell tumors: clinicopathologic review of 32 cases
Creators: K L Salzman - Department of Pathology, University of Florida College of Medicine, Gainesville 32610, USA
A M Rojiani
J Buatti
R G Quisling
R B Marcus Jr
B L Maria
J P Mickle
A Kedar
Resource Type: Journal article
Publication Details: Pediatric pathology & laboratory medicine, Vol.17(5), pp.713-728
Publisher: United States
DOI: 10.1080/15513819709168597
PMID: 9267886
ISSN: 1077-1042
eISSN: 1087-6529
Language: English
Date published: 09/1997
Academic Unit: Radiation Oncology; Neurosurgery; Otolaryngology
Record Identifier: 9984040206002771

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19 Times Cited - Web of Science