Primary sensory map formations reflect unique needs and molecular cues specific to each sensory system [version 1; peer review: 2 approved]

Bernd Fritzsch; Karen L Elliott; Gabriela Pavlinkova

doi:10.12688/f1000research.17717.1

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Primary sensory map formations reflect unique needs and molecular cues specific to each sensory system [version 1; peer review: 2 approved]

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Primary sensory map formations reflect unique needs and molecular cues specific to each sensory system [version 1; peer review: 2 approved]

Bernd Fritzsch, Karen L Elliott and Gabriela Pavlinkova

F1000 research, Vol.8, p.345

2019

DOI: 10.12688/f1000research.17717.1

PMCID: PMC6439788

PMID: 30984379

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https://doi.org/10.12688/f1000research.17717.1View

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Abstract

Interaction with the world around us requires extracting meaningful signals to guide behavior. Each of the six mammalian senses (olfaction, vision, somatosensation, hearing, balance, and taste) has a unique primary map that extracts sense-specific information. Sensory systems in the periphery and their target neurons in the central nervous system develop independently and must develop specific connections for proper sensory processing. In addition, the regulation of sensory map formation is independent of and prior to central target neuronal development in several maps. This review provides an overview of the current level of understanding of primary map formation of the six mammalian senses. Cell cycle exit, combined with incompletely understood molecules and their regulation, provides chemoaffinity-mediated primary maps that are further refined by activity. The interplay between cell cycle exit, molecular guidance, and activity-mediated refinement is the basis of dominance stripes after redundant organ transplantations in the visual and balance system. A more advanced level of understanding of primary map formation could benefit ongoing restoration attempts of impaired senses by guiding proper functional connection formations of restored sensory organs with their central nervous system targets.

olfactory map

cochleotopic map

taste map

primary sensory maps

vestibular map

retinotopic map

Details

Title: Subtitle: Primary sensory map formations reflect unique needs and molecular cues specific to each sensory system [version 1; peer review: 2 approved]
Creators: Bernd Fritzsch - Department of Biology, University of Iowa, Iowa City, USA
Karen L Elliott - Department of Biology, University of Iowa, Iowa City, USA
Gabriela Pavlinkova - Institute of Biotechnology of the Czech Academy of Sciences, Vestec, Czech Republic
Resource Type: Journal article
Publication Details: F1000 research, Vol.8, p.345
DOI: 10.12688/f1000research.17717.1
PMID: 30984379
PMCID: PMC6439788
NLM abbreviation: F1000Res
ISSN: 2046-1402
eISSN: 2046-1402
Grant note: R01AG060504 / NIH/NIA 17-04719S / Czech Science Fooundation 86652036 / Czech Acamady of Sciences R03DC015333 / NIH/NIDCD
Language: English
Date published: 2019
Academic Unit: Iowa Neuroscience Institute; Biology; Craniofacial Anomalies Research Center
Record Identifier: 9984070442402771

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