Journal article
Primary sleep disorders can cause long-term sleep disturbance in patients with autoimmune mediated limbic encephalitis
Clinical neurology and neurosurgery, Vol.115(7), pp.1079-1082
07/01/2013
DOI: 10.1016/j.clineuro.2012.10.031
PMID: 23177184
Abstract
Objectives: Antibody mediated limbic encephalitis causes a sub acute encephalopathy with an amnestic syndrome, seizures and often an affective prodrome. Sleep disturbance including abnormal dream sleep and insomnia are described in a percentage of long-term survivors but there are very few detailed assessments of sleep disturbance in patients beyond the acute phase of illness. The objectives of this study were to understand the causes of sleep disturbance in the long-term survivors of antibody mediated limbic encephalitis.
Patients and methods: We screened twelve patients under long-term follow up with sleep questionnaires and went on to perform detailed sleep studies (polysomnography) in those who reported sleep disturbance.
Results: Two were found to have persistent, severe central and obstructive sleep apnoea and two others to have restless legs and periodic limb movements of sleep.
Conclusions: This highlights the need to investigate sleep disturbance in this group of patients. Effective treatments may be available to improve quality of life and daytime function. (C) 2012 Elsevier B.V. All rights reserved.
Details
- Title: Subtitle
- Primary sleep disorders can cause long-term sleep disturbance in patients with autoimmune mediated limbic encephalitis
- Creators
- Kirstie N. Anderson - Royal Victoria Infirm, Dept Neurol, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, EnglandThomas P. Kelly - Newcastle Univ, Sch Med, Inst Neurosci, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, EnglandTimothy D. Griffiths - Newcastle Univ, Sch Med, Inst Neurosci, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
- Resource Type
- Journal article
- Publication Details
- Clinical neurology and neurosurgery, Vol.115(7), pp.1079-1082
- Publisher
- Elsevier
- DOI
- 10.1016/j.clineuro.2012.10.031
- PMID
- 23177184
- ISSN
- 0303-8467
- eISSN
- 1872-6968
- Number of pages
- 4
- Grant note
- 091681; 091593 / Wellcome Trust; European Commission
- Language
- English
- Date published
- 07/01/2013
- Academic Unit
- Psychological and Brain Sciences
- Record Identifier
- 9984627219102771
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