Primary tooth fluorosis and fluoride intake during the first year of life

Steven M Levy; Stephen L Hillis; John J Warren; Barbara A Broffitt; A K M Mahbubul Islam; James S Wefel; Michael J Kanellis

doi:10.1034/j.1600-0528.2002.00053.x

Journal article

Primary tooth fluorosis and fluoride intake during the first year of life

Steven M Levy, Stephen L Hillis, John J Warren, Barbara A Broffitt, A K M Mahbubul Islam, James S Wefel and Michael J Kanellis

Community dentistry and oral epidemiology, Vol.30(4), pp.286-295

08/2002

DOI: 10.1034/j.1600-0528.2002.00053.x

PMID: 12147170

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Abstract

Few studies in North America have assessed dental fluorosis of the primary dentition and few, if any, anywhere have assessed the relative importance in fluorosis etiology of fluoride intake during different time periods or from multiple sources. The purpose of this paper is to report on analyses relating estimated prenatal fluoride intake and fluoride intake during different parts of the first year of life to primary tooth fluorosis. As part of The Iowa Fluoride Study, subjects were recruited at birth and studied longitudinally. Trained examiners assessed dental fluorosis for children aged 4-7 years using the Tooth Surface Index of Fluorosis (TSIF) adapted for the primary dentition. Detailed parent questionnaires at childbirth were used to estimate prenatal fluoride intake and questionnaires sent at 6 weeks and 3, 6, 9, and 12 months were used to estimate fluoride intake during the first year of life (combined fluoride intake from water, food and beverage, supplements, and dentifrice). There were 504 children with prenatal and at least four of the five postnatal responses with complete data. Fluorosis prevalence was 12.1%, occurring primarily on the second primary molars. Receiver operating characteristic (ROC) curves and logistic regression were used to assess the importance of different time periods' fluoride intake. In bivariate analyses, fluoride intake during each time interval was individually significantly related to fluorosis occurrence. For multivariate analyses, the period from 6 to 9 months was most important individually (P = 0.0001), and no other period was jointly statistically significant. Results suggest that the middle of the first year of life is most important in fluorosis etiology for the primary dentition in this setting.

Prenatal Exposure Delayed Effects

Demography

Prevalence

Area Under Curve

Humans

Child, Preschool

Infant

Male

Cariostatic Agents - administration & dosage

Fluorosis, Dental - epidemiology

Fluorides - adverse effects

Sensitivity and Specificity

Cariostatic Agents - adverse effects

Female

Iowa - epidemiology

Surveys and Questionnaires

Child

Fluorides - administration & dosage

Food

Fluorosis, Dental - etiology

Logistic Models

Dentifrices

Pregnancy

Fluoridation

ROC Curve

Tooth, Deciduous

Dietary Supplements

Details

Title: Subtitle: Primary tooth fluorosis and fluoride intake during the first year of life
Creators: Steven M Levy - Department of Preventive and Community Dentistry, University of Iowa College of Dentistry, Iowa City, IA 52242, USA. steven-levy@uiowa.edu
Stephen L Hillis
John J Warren
Barbara A Broffitt
A K M Mahbubul Islam
James S Wefel
Michael J Kanellis
Resource Type: Journal article
Publication Details: Community dentistry and oral epidemiology, Vol.30(4), pp.286-295
Publisher: Denmark
DOI: 10.1034/j.1600-0528.2002.00053.x
PMID: 12147170
ISSN: 0301-5661
eISSN: 1600-0528
Grant note: P30-DE10126 / NIDCR NIH HHS R01-DE09551 / NIDCR NIH HHS CRC-RR00059 / CCR NIH HHS
Language: English
Date published: 08/2002
Academic Unit: Preventive and Community Dentistry; Radiology; Epidemiology; Dental Clinic Administration; Biostatistics; Pediatric Dentistry
Record Identifier: 9983917776102771

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