Priming deficiency in male subjects at risk for alcoholism: the N4 during a lexical decision task

Bangalore N Roopesh; Madhavi Rangaswamy; Chella Kamarajan; David B Chorlian; Arthur Stimus; Lance O Bauer; John Rohrbaugh; Sean J O'Connor; Samuel Kuperman; Marc Schuckit; Bernice Porjesz

doi:10.1111/j.1530-0277.2009.01042.x

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Priming deficiency in male subjects at risk for alcoholism: the N4 during a lexical decision task

Journal article

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Priming deficiency in male subjects at risk for alcoholism: the N4 during a lexical decision task

Bangalore N Roopesh, Madhavi Rangaswamy, Chella Kamarajan, David B Chorlian, Arthur Stimus, Lance O Bauer, John Rohrbaugh, Sean J O'Connor, Samuel Kuperman, Marc Schuckit, …

Alcoholism, clinical and experimental research, Vol.33(12), pp.2027-2036

12/2009

DOI: 10.1111/j.1530-0277.2009.01042.x

PMCID: PMC3601897

PMID: 19764939

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Abstract

While there is extensive literature on the relationship between the P3 component of event-related potentials (ERPs) and risk for alcoholism, there are few published studies regarding other potentially important ERP components. One important candidate is the N4(00) component in the context of semantic processing, as abnormalities in this component have been reported for adult alcoholics. A semantic priming task was administered to nonalcohol dependent male offspring (18 to 25 years) of alcoholic fathers [high risk (HR) n = 23] and nonalcoholic fathers [low risk (LR) n = 28] to study whether the 2 groups differ in terms of the N4 component. Subjects were presented with 150 words and 150 nonwords. Among the words, 50 words (primed) were preceded by their antonyms (prime, n = 50), whereas the remaining 50 words were unprimed. For the analysis, N4 amplitude and latency as well as behavioral measures for the primed and unprimed words were considered. A significant interaction effect was observed between semantic condition and group, where HR subjects did not show N4 attenuation for primed stimuli. The lack of N4 attenuation to primed stimuli and/or inability to differentiate between primed and unprimed stimuli, without latency and reaction time being affected, suggest deficits in semantic priming, especially in semantic expectancy and/or postlexical semantic processing in HR male offspring. Further, it indicates that it might be an electrophysiological endophenotype that reflects genetic vulnerability to develop alcoholism.

Electrophysiology

Psycholinguistics

Cues

Humans

Male

Risk

Psychomotor Performance - drug effects

Alcoholism - epidemiology

Evoked Potentials - drug effects

Young Adult

Electroencephalography - drug effects

Alcoholism - genetics

Decision Making - physiology

Alcoholism - psychology

Details

Title: Subtitle: Priming deficiency in male subjects at risk for alcoholism: the N4 during a lexical decision task
Creators: Bangalore N Roopesh - Henri Begleiter Neurodynamics Laboratory, Department of Psychiatry and Behavioral Sciences, State University of New York-Downstate Medical Center at Brooklyn, 450 Clarkson Ave., Brooklyn, NY 11203, USA
Madhavi Rangaswamy
Chella Kamarajan
David B Chorlian
Arthur Stimus
Lance O Bauer
John Rohrbaugh
Sean J O'Connor
Samuel Kuperman
Marc Schuckit
Bernice Porjesz
Resource Type: Journal article
Publication Details: Alcoholism, clinical and experimental research, Vol.33(12), pp.2027-2036
DOI: 10.1111/j.1530-0277.2009.01042.x
PMID: 19764939
PMCID: PMC3601897
NLM abbreviation: Alcohol Clin Exp Res
ISSN: 1530-0277
eISSN: 1530-0277
Publisher: Wiley; England
Grant note: U10 AA 008401 / NIAAA NIH HHS U10 AA008401-18S1 / NIAAA NIH HHS U10 AA008401 / NIAAA NIH HHS
Language: English
Date published: 12/2009
Academic Unit: Psychiatry; Stead Family Department of Pediatrics
Record Identifier: 9984003455502771

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