Journal article
Prism adaptation in schizophrenia
Brain and cognition, Vol.61(3), pp.235-242
2006
DOI: 10.1016/j.bandc.2006.01.004
PMID: 16510223
Abstract
The prism adaptation test examines procedural learning (PL) in which performance facilitation occurs with practice on tasks without the need for conscious awareness. Dynamic interactions between frontostriatal cortices, basal ganglia, and the cerebellum have been shown to play key roles in PL. Disruptions within these neural networks have also been implicated in schizophrenia, and such disruptions may manifest as impairment in prism adaptation test performance in schizophrenia patients. This study examined prism adaptation in a sample of patients diagnosed with schizophrenia (
N
=
91) and healthy normal controls (
N
=
58). Quantitative indices of performance during prism adaptation conditions with and without visual feedback were studied. Schizophrenia patients were significantly more impaired in adapting to prism distortion and demonstrated poorer quality of PL. Patients did not differ from healthy controls on aftereffects when the prisms were removed, but they had significantly greater difficulties in reorientation. Deficits in prism adaptation among schizophrenia patients may be due to abnormalities in motor programming arising from the disruptions within the neural networks that subserve PL.
Details
- Title: Subtitle
- Prism adaptation in schizophrenia
- Creators
- Nirav O BigelowBeth M TurnerNancy C AndreasenJane S PaulsenDaniel S O’LearyBeng-Choon Ho
- Resource Type
- Journal article
- Publication Details
- Brain and cognition, Vol.61(3), pp.235-242
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.bandc.2006.01.004
- PMID
- 16510223
- ISSN
- 0278-2626
- eISSN
- 1090-2147
- Language
- English
- Date published
- 2006
- Academic Unit
- Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984003985502771
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