Journal article
Pro-Con Debate: Opioids and Perioperative Organ Injury—Friend or Foe?
Anesthesia and analgesia, Vol.142(5), pp.832-842
05/2026
DOI: 10.1213/ANE.0000000000007707
PMID: 40779428
Abstract
In this pro-con, we discuss the topic of opioids and organ protection. With the recent shift in providing opioid-sparing surgeries, it is imperative to understand whether opioids, administered routinely for surgeries over the past several decades, provide an added benefit of organ protection. This is an area of debate, as the possible benefits of opioid-mediated organ protection must be carefully weighed against the potential drawbacks of acute opioid administration, such as immunosuppression, hyperalgesia, and constipation.
Details
- Title: Subtitle
- Pro-Con Debate: Opioids and Perioperative Organ Injury—Friend or Foe?
- Creators
- Detlef Obal - University of IowaAndrew Notarianni - Yale UniversityLoren E. Smith - Vanderbilt University Medical CenterEric R. Gross - Stanford University
- Resource Type
- Journal article
- Publication Details
- Anesthesia and analgesia, Vol.142(5), pp.832-842
- DOI
- 10.1213/ANE.0000000000007707
- PMID
- 40779428
- NLM abbreviation
- Anesth Analg
- ISSN
- 0003-2999
- eISSN
- 1526-7598
- Publisher
- Lippincott
- Language
- English
- Electronic publication date
- 08/08/2025
- Date published
- 05/2026
- Academic Unit
- Anesthesia
- Record Identifier
- 9984949239402771