Journal article
Pro-inflammatory profiles in cardiovascular disease patients with peri-implantitis
Journal of periodontology (1970), Vol.93(6), pp.824-836
06/01/2022
DOI: 10.1002/JPER.21-0419
PMID: 34807456
Abstract
Background To investigate the pro-inflammatory cytokine profiles in patients with or without cardiovascular disease (CVD) and with or without peri-implantitis. Methods Serum, peri-implant crevicular fluid (PICF), and gingival crevicular fluid (GCF) were collected from patients with (n = 82) or without CVD (n = 46) at the most severe peri-implantitis site including sites with periodontitis. A panel of proinflammatory molecules including high-sensitivity C-reactive protein (hsCRP), fibrinogen, interleukin-1 beta (IL-1 beta), IL-6, plasma tumor necrosis factor-alpha (TNF-alpha), matrix metallo-proteinase-8 (MMP-8), osteoprotegerin (OPG), vascular endothelial growth factor (VEGF), IL-17, IL-8, tissue inhibitor of metalloproteinase-2 (TIMP-2), myeloperoxidase (MPO), and prostaglandin E-2 (PGE(2)) were analyzed using human custom Quantibody arrays. Krunskal-Wallis test was used to compare groups. The diagnostic ability of each biomarker was assessed using chi-square test and ROC analysis. Results Serum IL-1 beta, TNF-alpha and fibrinogen were significantly higher in CVD patients than those without. Serum fibrinogen displayed a trend of higher concentration in patients with radiographic bone loss (RBL) >= 2 mm (P = 0.08). PICF TNF-alpha exhibited a significantly higher detection level in the CVD patients that is coincided with the local peri-implant inflammation. In addition, PICF MMP-8 was significantly higher in the RBL >= 2 mm sites than the healthy implants; whereas IL-1 beta, IL-8, MMP-8, and TIMP-2 proved to be the significant predictors for peri-implant disease. GCF TNF-alpha collected from patients with periodontitis was significantly associated with CVD cases. Conclusion The augmented expression of local and systemic pro-inflammatory cytokines found in the current study supports the weak association between the chronic peri-implantitis with increasing severity and CVD.
Details
- Title: Subtitle
- Pro-inflammatory profiles in cardiovascular disease patients with peri-implantitis
- Creators
- I-Ching Wang - University of MichiganJim Sugai - University of MichiganJad Majzoub - University of MichiganJeffery Johnston - University of MichiganWilliam Giannobile - University of MichiganHom-Lay Wang - University of Michigan
- Resource Type
- Journal article
- Publication Details
- Journal of periodontology (1970), Vol.93(6), pp.824-836
- DOI
- 10.1002/JPER.21-0419
- PMID
- 34807456
- NLM abbreviation
- J Periodontol
- ISSN
- 0022-3492
- eISSN
- 1943-3670
- Publisher
- Wiley
- Number of pages
- 13
- Grant note
- Delta Dental Research Fund from The Delta Dental Foundation at Michigan Graduate Student Research Fund at the University of Michigan
- Language
- English
- Date published
- 06/01/2022
- Academic Unit
- Periodontics
- Record Identifier
- 9984367745302771
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