Journal article
Probability of Obsessive and Compulsive Symptoms in Huntington’s Disease
Biological psychiatry (1969), Vol.61(3), pp.415-418
2007
DOI: 10.1016/j.biopsych.2006.04.034
PMID: 16839521
Abstract
The purpose of this study was to examine the probability of obsessive and compulsive (OC) symptoms across stages of Huntington’s disease (HD) with both cross sectional and longitudinal data.
We present the largest sample to date of individuals at risk for HD (
N = 3964). Obsessive and compulsive symptoms were assessed with the Unified Huntington’s Disease Rating Scale OC items.
The probability of meeting the threshold for obsessions and compulsions increased with greater disease severity. Those with no motor abnormalities (“at risk”) had a 7% probability of obsessions and a 3.5% probability of compulsions; the peak probability for obsessions (24%) and compulsions (12%) occurred in patients with advanced disease with significant functional disability.
The probability of OC symptoms is more than three times greater by stages 3 and 4 (clearly manifest disease) than in our at-risk group with no apparent motor abnormalities.
Details
- Title: Subtitle
- Probability of Obsessive and Compulsive Symptoms in Huntington’s Disease
- Creators
- Leigh J Beglinger - Department of Psychiatry, University of Iowa, Iowa City, IowaDouglas R Langbehn - Department of Psychiatry, University of Iowa, Iowa City, IowaKevin Duff - Department of Psychiatry, University of Iowa, Iowa City, IowaLaura Stierman - Department of Biostatistics, University of Iowa, Iowa City, IowaDonald W Black - Department of Psychiatry, University of Iowa, Iowa City, IowaCarissa Nehl - Department of Psychology, University of Iowa, Iowa City, IowaKaren Anderson - Departments of Psychiatry and Neurology University of Maryland, College Park, MarylandElizabeth Penziner - Department of Psychiatry, University of Iowa, Iowa City, IowaJane S Paulsen - Department of Psychiatry, University of Iowa, Iowa City, IowaHuntington Study Group Investigators
- Resource Type
- Journal article
- Publication Details
- Biological psychiatry (1969), Vol.61(3), pp.415-418
- DOI
- 10.1016/j.biopsych.2006.04.034
- PMID
- 16839521
- NLM abbreviation
- Biol Psychiatry
- ISSN
- 0006-3223
- eISSN
- 1873-2402
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 2007
- Academic Unit
- Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984004087902771
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