Journal article
Probing cells with noble metal nanoparticle aggregates
Nanomedicine, Vol.3(4), pp.555-565
08/01/2008
DOI: 10.2217/17435889.3.4.555
PMID: 18694317
Abstract
This review focuses on the integration of noble metal nanoparticle aggregates as tags and transport vessels in cellular applications. The natural tendency of nanoparticles to aggregate can be reduced through surface modification; however, this stabilization is often compromised in the cellular environment. The degree of nanoparticle aggregation has both positive and negative consequences. Nanoparticle aggregates are more efficiently removed by the organism compared with single nanoparticles, preventing delivery to their cellular target. In addition, these aggregates are recognized by cells in different ways versus isolated nanoparticles. Despite these negatives, aggregates exhibit enhancement for many detection and treatment techniques in comparison with single nanoparticles. In coming years, the role of aggregates and better control over the degree of aggregation in cellular studies will be required for the realization of medical applications.
Details
- Title: Subtitle
- Probing cells with noble metal nanoparticle aggregates
- Creators
- Maryuri RocaAmanda J Haes
- Resource Type
- Journal article
- Publication Details
- Nanomedicine, Vol.3(4), pp.555-565
- Publisher
- Future Medicine Ltd
- DOI
- 10.2217/17435889.3.4.555
- PMID
- 18694317
- ISSN
- 1743-5889
- eISSN
- 1748-6963
- Language
- English
- Date published
- 08/01/2008
- Academic Unit
- Chemistry
- Record Identifier
- 9983985866702771
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