Probing the effects of phosphoinositides on ion channels

Chou-Long Huang

doi:10.1385/1-59745-095-2:81

Back

Journal article

Probing the effects of phosphoinositides on ion channels

Chou-Long Huang

Methods in molecular biology (Clifton, N.J.), Vol.337, pp.81-87

2006

DOI: 10.1385/1-59745-095-2:81

PMID: 16929940

View Online

Abstract

Ion channels are integral membrane proteins that control transmembrane ion fluxes to regulate membrane potential, cell excitability, and ion transport. Membrane phospholipids containing phosphoinositides have recently emerged as important regulators of many ion channels, including inward rectifier K+ channel, voltage-gated K+ and Ca2+ channels, transient receptor potential channels, and intracellular inositol-1,4,5-trisphosphate receptor ion channels. Discussed here are several methods for studying regulation of ion channels by phospholipids.

Animals

Cattle

CHO Cells

Cricetinae

Cricetulus

Ion Channels - metabolism

Patch-Clamp Techniques

Phosphatidylinositol 4,5-Diphosphate - metabolism

Phosphatidylinositol 4,5-Diphosphate - pharmacology

Receptors, Cell Surface - metabolism

Type C Phospholipases - metabolism

Details

Title: Subtitle: Probing the effects of phosphoinositides on ion channels
Creators: Chou-Long Huang - Southwestern Medical Center
Resource Type: Journal article
Publication Details: Methods in molecular biology (Clifton, N.J.), Vol.337, pp.81-87
DOI: 10.1385/1-59745-095-2:81
PMID: 16929940
eISBN: 9781597450959; 1597450952
ISSN: 1064-3745
eISSN: 1940-6029
Grant note: DK54368 / NIDDK NIH HHS DK59530 / NIDDK NIH HHS DK20543 / NIDDK NIH HHS
Language: English
Date published: 2006
Academic Unit: Nephrology; Internal Medicine
Record Identifier: 9984359569502771

Metrics

4 Record Views