Proceedings of the Sleep and Epilepsy Workshop: Section 3 Mortality: Sleep, Night, and SUDEP

Gordon F Buchanan; Bruce J Gluckman; Franck K Kalume; Samden Lhatoo; Rama K Maganti; Jeffrey L Noebels; Kristina A Simeone; Mark S Quigg; Milena K Pavlova

doi:10.1177/15357597211004556

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Proceedings of the Sleep and Epilepsy Workshop: Section 3 Mortality: Sleep, Night, and SUDEP

Journal article

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Proceedings of the Sleep and Epilepsy Workshop: Section 3 Mortality: Sleep, Night, and SUDEP

Gordon F Buchanan, Bruce J Gluckman, Franck K Kalume, Samden Lhatoo, Rama K Maganti, Jeffrey L Noebels, Kristina A Simeone, Mark S Quigg and Milena K Pavlova

Epilepsy currents, Vol.21(3), pp.215-219

03/31/2021

DOI: 10.1177/15357597211004556

PMID: 33787378

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Abstract

Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients with refractory epilepsy. Likely pathophysiological mechanisms include seizure-induced cardiac and respiratory dysregulation. A frequently identified feature in SUDEP cases is that they occur at night. This raises the question of a role for sleep state in regulating of SUDEP. An association with sleep has been identified in a number of studies with patients and in animal models. The focus of this section of the Sleep and Epilepsy Workshop was on identifying and understanding the role for sleep and time of day in the pathophysiology of SUDEP.

Epilepsy

sleep

dysregulation

pathophysiological mechanisms

SUDEP

comorbidities

Details

Title: Subtitle: Proceedings of the Sleep and Epilepsy Workshop: Section 3 Mortality: Sleep, Night, and SUDEP
Creators: Gordon F Buchanan - Department of Neurology and Iowa Neuroscience Institute, 12243University of Iowa Carver College of Medicine, Iowa City, IA, USA
Bruce J Gluckman - Department of Biomedical Engineering, 8082Penn State University, University Park, PA, USA
Franck K Kalume - Department of Neurological Surgery, University of Washington and 145793Seattle Children's Research Institute, Seattle, WA, USA
Samden Lhatoo - Department of Neurology, 12339University of Texas McGovern Medical School, Houston, TX, USA
Rama K Maganti - Department of Neurology, 5228University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
Jeffrey L Noebels - Department of Molecular & Human Genetics, 3989Baylor College of Medicine, Houston, TX, USA
Kristina A Simeone - Department of Pharmacology & Neuroscience, 12282Creighton University School of Medicine, Omaha, NE, USA
Mark S Quigg - Department of Neurology, 12350University of Virginia School of Medicine, Charlottesville, VA, USA
Milena K Pavlova - Department of Neurology, 1861Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA
Resource Type: Journal article
Publication Details: Epilepsy currents, Vol.21(3), pp.215-219
DOI: 10.1177/15357597211004556
PMID: 33787378
NLM abbreviation: Epilepsy Curr
ISSN: 1535-7597
eISSN: 1535-7511
Publisher: United States
Grant note: DOI: 10.13039/100019323, name: The Band Foundation
Language: English
Date published: 03/31/2021
Academic Unit: Neurology; Iowa Neuroscience Institute
Record Identifier: 9984070415702771

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