Journal article
Procyanidins extracted from the litchi pericarp ameliorate atherosclerosis in ApoE knockout mice: their effects on nitric oxide bioavailability and oxidative stress
Food & function, Vol.8(11), pp.4210-4216
11/15/2017
DOI: 10.1039/c7fo00747g
PMID: 29043330
Abstract
Epidemiological studies strongly support the role of procyanidin-rich beverages and fruit in the prevention of cardiovascular diseases. Procyanidins extracted from the litchi pericarp (LPPC), a new source of procyanidins, were isolated and identified in our laboratory and have been proven to possess strong antioxidant activity in vitro. In the present study, we investigated the anti-atherosclerotic effects of LPPC in apolipoprotein E knockout (ApoE KO) mice fed a high fat diet for 24 weeks. LPPC (100 mg kg
body mass daily) significantly reduced the atherosclerotic lesion size (P < 0.01 versus ApoE KO mice), excess NO production and iNOS expression. Moreover, the mRNA and protein expressions of eNOS in the aortas of ApoE KO mice were increased by LPPC which further explains the endothelial protective action of LPPC. LPPC also showed profound antioxidant effects in ApoE KO mice. Plasma TBARS contents and the mRNA expression for NADPH oxidase (p47
, p67
, NOX-2/gp91
and NOX-4) in the aortas of ApoE KO mice were significantly reduced, whereas plasma SOD activity was markedly elevated by LPPC. These results elucidated that LPPC could ameliorate atherosclerosis in ApoE-KO mice by improving NO bioavailability and reducing oxidative stress through NADPH oxidase-dependent mechanisms.
Details
- Title: Subtitle
- Procyanidins extracted from the litchi pericarp ameliorate atherosclerosis in ApoE knockout mice: their effects on nitric oxide bioavailability and oxidative stress
- Creators
- Shuang Rong - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. lgliu@mails.tjmu.edu.cnXueting HuSiqi ZhaoYanting ZhaoXiao Xiao - Huazhong University of Science and TechnologyWei BaoLiegang Liu
- Resource Type
- Journal article
- Publication Details
- Food & function, Vol.8(11), pp.4210-4216
- Publisher
- England
- DOI
- 10.1039/c7fo00747g
- PMID
- 29043330
- ISSN
- 2042-6496
- eISSN
- 2042-650X
- Grant note
- DOI: 10.13039/501100001809, name: National Natural Science Foundation of China, award: NSFC- u0731005, 81072291
- Language
- English
- Date published
- 11/15/2017
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9983995178402771
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