Journal article
Production of pyrogenic exotoxin by groups of streptococci: association with group A
The Journal of infectious diseases, Vol.140(5), pp.676-681
11/1979
DOI: 10.1093/infdis/140.5.676
PMID: 393776
Abstract
Several groups of streptococci were tested for production of pyrogenic exotoxins (SPE) with Ouchterlony immunodiffusion, a newly developed passive hemagglutination inhibition assay, and an assay for pyrogenicity and capacity to enhance lethal endotoxin shock. With use of these assays, 68 (91%) of 75 group A streptococcal strains were positive for one or more of SPE types A, B, and C; seven were negative for both the known SPE types and antigenically unrelated pyrogenic exotoxins. Group A strains producing both SPE B and C were the most common, and strains producing A alone or AB and AC together were the least common. All of 11 rheumatogenic group A streptococci elaborated SPE C either alone or together with one or both of SPE types A and B. The 10 nephritogenic strains tested were positive for SPE B; five were positive for B alone. In contrast to group A streptococci, non-group A strains (41 tested) did not produce the known SPE types, and 19 of 19 tested were negative for antigenically unrelated pyrogenic exotoxins. Group A strains from Holland, India, and Japan also elaborated SPE. Several group A streptococci used widely in laboratory experiments were tested for SPE types produced.
Details
- Title: Subtitle
- Production of pyrogenic exotoxin by groups of streptococci: association with group A
- Creators
- P M SchlievertK M BettinD W Watson
- Resource Type
- Journal article
- Publication Details
- The Journal of infectious diseases, Vol.140(5), pp.676-681
- Publisher
- United States
- DOI
- 10.1093/infdis/140.5.676
- PMID
- 393776
- ISSN
- 0022-1899
- eISSN
- 1537-6613
- Language
- English
- Date published
- 11/1979
- Academic Unit
- Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984002381102771
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