Journal article
Production of ribosome components in effector CD4+ T cells is accelerated by TCR stimulation and coordinated by ERK-MAPK
Immunity (Cambridge, Mass.), Vol.19(4), pp.535-548
10/2003
DOI: 10.1016/S1074-7613(03)00268-1
PMID: 14563318
Abstract
Effector CD4+ T cells rapidly activate high-level cytokine expression following TCR stimulation. Consistent with accelerated protein production in these cells, global mRNA profiles revealed that, after cytokines, the most impressive cluster of activated genes encode rRNA-maturation factors. Activation of these genes was ERK-MAPK dependent, accompanied by increased rRNA transcription and faster maturation kinetics, and much greater in effector CD4+ T cells than in naive cells. Ribosomal protein subunit (RPS) synthesis was also ERK-MAPK dependent and increased to match rRNA production, but without evident increase in RPS mRNA. Instead, stimulation promoted polysome loading of RPS mRNA via cis-acting, 5'-terminal oligopyrimidines. These results demonstrate how, in response to extracellular signals, effector CD4+ T cells coordinately increase multiple ribosomal components to accommodate burgeoning cytokine production.
Details
- Title: Subtitle
- Production of ribosome components in effector CD4+ T cells is accelerated by TCR stimulation and coordinated by ERK-MAPK
- Creators
- Mohammed Asmal - Department of Microbiology, Columbia University College of Physicians and Surgeons, 701 West 168th Street, New York, NY 10032, USAJohn ColganFelix NaefBin YuYoungnam LeeMarcelo MagnascoJeremy Luban
- Resource Type
- Journal article
- Publication Details
- Immunity (Cambridge, Mass.), Vol.19(4), pp.535-548
- Publisher
- United States
- DOI
- 10.1016/S1074-7613(03)00268-1
- PMID
- 14563318
- ISSN
- 1074-7613
- eISSN
- 1097-4180
- Grant note
- R01 AI036199 / NIAID NIH HHS AI 36199 / NIAID NIH HHS
- Language
- English
- Date published
- 10/2003
- Academic Unit
- Anatomy and Cell Biology; Immunology; Internal Medicine
- Record Identifier
- 9984025559202771
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