Journal article
Production of toxic shock syndrome-like illness in rabbits by Staphylococcus aureus D4508: association with enterotoxin A
Infection and immunity, Vol.58(7), pp.2067-2070
07/1990
DOI: 10.1128/IAI.58.7.2067-2070.1990
PMCID: PMC258777
PMID: 2365451
Abstract
Staphylococcus aureus D4508, obtained from a patient with nonmenstrual toxic shock syndrome (TSS), produced enterotoxin A while not making other known enterotoxins or TSS toxin 1. Concentrated culture fluids of the organism, administered subcutaneously in miniosmotic pumps, induced TSS-like symptoms (four of six animals succumbed). Identical culture fluids pretreated with anti-enterotoxin A serum failed to induce symptoms except for fever (none of six animals succumbed). Purified staphylococcal enterotoxin A also had the ability to induce TSS-like symptoms. These data suggest that enterotoxin A is the major TSS-associated toxin made by strain D4508.
Details
- Title: Subtitle
- Production of toxic shock syndrome-like illness in rabbits by Staphylococcus aureus D4508: association with enterotoxin A
- Creators
- Bruce D McCollister - Department of Microbiology, University of Minnesota, Minneapolis 55455Barry N KreiswirthRichard P NovickPatrick M Schlievert
- Resource Type
- Journal article
- Publication Details
- Infection and immunity, Vol.58(7), pp.2067-2070
- Publisher
- United States
- DOI
- 10.1128/IAI.58.7.2067-2070.1990
- PMID
- 2365451
- PMCID
- PMC258777
- ISSN
- 0019-9567
- eISSN
- 1098-5522
- Grant note
- AI-22159 / NIAID NIH HHS
- Language
- English
- Date published
- 07/1990
- Academic Unit
- Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984001114602771
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