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Profiles of obesity, weight gain, and quality of life in idiopathic intracranial hypertension (pseudotumor cerebri)
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Profiles of obesity, weight gain, and quality of life in idiopathic intracranial hypertension (pseudotumor cerebri)

Anthony B Daniels, Grant T Liu, Nicholas J Volpe, Steven L Galetta, Mark L Moster, Nancy J Newman, Valerie Biousse, Andrew G Lee, Michael Wall, Randy Kardon, …
American journal of ophthalmology, Vol.143(4), pp.635-641.e1
04/2007
DOI: 10.1016/j.ajo.2006.12.040
PMID: 17386271

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Abstract

Obesity and weight gain are known risk factors for idiopathic intracranial hypertension (IIH; or pseudotumor cerebri). The authors examined profiles of body mass index (BMI) and patterns of weight gain associated with IIH. They also examined vision-specific health-related quality of life (HRQOL) in newly diagnosed IIH patients and explored the relative contribution of obesity and weight gain to overall HRQOL in this disorder. Matched case-control study. Female patients with newly diagnosed IIH (n = 34) and other neuro-ophthalmologic disorders (n = 41) were enrolled in a case-control study to assess patterns of self-reported weight gain. The HRQOL was examined using the 25-Item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25) and the SF-36 Health Survey (Physical Components Summary and Mental Components Summary [MCS]). Higher BMIs were associated with greater risk of IIH (P = .003, logistic regression analysis adjusting for case-control matching), as were higher percentages of weight gain during the year before symptom onset (P = .004). Moderate weight gain (5% to 15%) was associated with a greater risk of IIH among both obese and nonobese patients. Obesity and weight gain influenced the relation between HRQOL and IIH only for subscale scores reflecting mental health (SF-36 MCS). The NEI-VFQ-25 and SF-36 subscale scores were lower in IIH compared with other neuro-ophthalmologic disorders and published norms. Higher levels of weight gain and BMI are associated with greater risk of IIH. Even nonobese patients (BMI <30) are at greater risk for IIH in the setting of moderate weight gain. Vision-specific and overall HRQOL are affected to a greater extent in IIH than in other neuro-ophthalmologic disorders.
 Quality of Life Body Mass Index Obesity - complications Humans Middle Aged Risk Factors Obesity - physiopathology Case-Control Studies Cerebrospinal Fluid Pressure Pseudotumor Cerebri - physiopathology Pseudotumor Cerebri - etiology Adolescent Adult Female Surveys and Questionnaires Health Status Weight Gain

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