Progenitor Resilience and the Early Onset of Chronic Lung Diseases: NHLBI workshop report

SeungHye Han; Anny Xiaobo Zhou; Amanda M Jamieson; Andrew A Wilson; Bin Zhou; Daniel J Weiss; Dianhua Jiang; Frank McKeon; Harold Chapman; Helen Miranda; Herbert B Schiller; Jayaraj Rajagopal; Jeong H Yun; Jianwen Que; John F Engelhardt; Maria C Basil; Micha Sam Brickman Raredon; Mingxia Gu; Moumita Ghosh; Preetish Kadur Lakshminarasimha Murthy; Purushothama Rao Tata; Ruobing Wang; Shawn Davidson; Susan M Majka; Yohannes Tesfaigzi; Christian R Gomez; Qing Lu; Jose Ordovas-Montanes; Ravi Kalhan

doi:10.1093/ajrcmb/aanag107

Back

Progenitor Resilience and the Early Onset of Chronic Lung Diseases: NHLBI workshop report

Journal article

Open access

Peer reviewed

Progenitor Resilience and the Early Onset of Chronic Lung Diseases: NHLBI workshop report

SeungHye Han, Anny Xiaobo Zhou, Amanda M Jamieson, Andrew A Wilson, Bin Zhou, Daniel J Weiss, Dianhua Jiang, Frank McKeon, Harold Chapman, Helen Miranda, …

American journal of respiratory cell and molecular biology

05/27/2026

DOI: 10.1093/ajrcmb/aanag107

PMID: 42202213

Files and links (1)

url

https://doi.org/10.1093/ajrcmb/aanag107View

Published (Version of record) Open Access

Abstract

Lung function peaks in young adulthood and declines with age. Studies suggest that this trajectory may be modifiable, potentially enhancing lung health and resilience to prevent or delay the onset of chronic lung disease. Although significant progress has been made in identifying the lung stem/progenitor cell populations involved in lung repair and homeostasis, their regulation and potential for manipulation to promote respiratory health and resilience remain elusive. To explore these issues, the NHLBI organized a virtual workshop on November 7-8, 2024 that aimed to cover the current scientific landscape, address critical research gaps, and identify challenges, opportunities, and key research questions related to chronic lung disease, with a focus on lung stem/progenitor resilience and its applications in the early diagnosis, prevention, and treatment of chronic lung diseases. This report summarizes the scientific presentations, discussions, and recommendations from the workshop.

Details

Title: Subtitle: Progenitor Resilience and the Early Onset of Chronic Lung Diseases: NHLBI workshop report
Creators: SeungHye Han - Northwestern University
Anny Xiaobo Zhou - University of Virginia
Amanda M Jamieson - Brown University
Andrew A Wilson - Boston University
Bin Zhou - Center for Excellence in Molecular Cell Science
Daniel J Weiss - University of Vermont
Dianhua Jiang - Cedars-Sinai Medical Center
Frank McKeon - University of Houston
Harold Chapman - University of California, San Francisco
Helen Miranda - Case Western Reserve University
Herbert B Schiller - German Center for Lung Research
Jayaraj Rajagopal - Massachusetts General Hospital
Jeong H Yun - Brigham and Women's Hospital
Jianwen Que - Columbia University
John F Engelhardt - University of Alabama at Birmingham
Maria C Basil - University of Pennsylvania
Micha Sam Brickman Raredon - Yale University
Mingxia Gu - University of California, Los Angeles
Moumita Ghosh - University of Colorado Anschutz Medical Campus
Preetish Kadur Lakshminarasimha Murthy - University of Illinois Chicago
Purushothama Rao Tata - Duke University
Ruobing Wang - Harvard University
Shawn Davidson - Northwestern University
Susan M Majka - Harvard University
Yohannes Tesfaigzi - Brigham and Women's Hospital
Christian R Gomez - National Jewish Health
Qing Lu - National Jewish Health
Jose Ordovas-Montanes - Broad Institute
Ravi Kalhan - Northwestern University
Resource Type: Journal article
Publication Details: American journal of respiratory cell and molecular biology
DOI: 10.1093/ajrcmb/aanag107
PMID: 42202213
NLM abbreviation: Am J Respir Cell Mol Biol
ISSN: 1535-4989
eISSN: 1535-4989
Publisher: Oxford University Press
Language: English
Electronic publication date: 05/27/2026
Academic Unit: Anatomy and Cell Biology
Record Identifier: 9985166963202771

Metrics

1 Record Views