Progesterone receptor expression is a marker for early stage breast cancer: Implications for progesterone receptor as a therapeutic tool and target

Yvonne M Coyle; Xian-Jin Xie; Daniel B Hardy; Raheela Ashfaq; Carole R Mendelson

doi:10.1016/j.canlet.2007.09.011

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Progesterone receptor expression is a marker for early stage breast cancer: Implications for progesterone receptor as a therapeutic tool and target

Journal article

Peer reviewed

Progesterone receptor expression is a marker for early stage breast cancer: Implications for progesterone receptor as a therapeutic tool and target

Yvonne M Coyle, Xian-Jin Xie, Daniel B Hardy, Raheela Ashfaq and Carole R Mendelson

Cancer Letters, Vol.258(2), pp.253-261

2007

DOI: 10.1016/j.canlet.2007.09.011

PMID: 17950525

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Abstract

We determined the association of estrogen receptor (ER) and progesterone receptor (PR) expression in invasive breast cancer with stage at diagnosis. Univariate analyses indicated that although ER and PR expression were inversely associated with grade ( P < 0.0001), only PR expression ( P < 0.01) was inversely associated with stage. Multivariate analyses, adjusted for covariates, including HER-2/neu expression, indicated that PR (odds ratio (OR), 0.88; confidence interval (CI), 0.77–0.99; P = 0.03) and not ER expression (OR, 1.04; CI, 0.94–1.16; P = 0.45) was inversely associated with stage. PR and not ER expression is a marker for early stage breast cancer.

Tumor stage

Estrogen receptor

Breast cancer

Progesterone receptor

Disease progression

Details

Title: Subtitle: Progesterone receptor expression is a marker for early stage breast cancer: Implications for progesterone receptor as a therapeutic tool and target
Creators: Yvonne M Coyle - UT Southwestern Medical Center, Department of Medicine, Hamon Center for Therapeutic Oncology Research, 5323 Harry Hines Boulevard, Dallas, TX 75390-9103, USA
Xian-Jin Xie - UT Southwestern Medical Center, Department of Clinical Sciences, Division of Biostatistics, 5323 Harry Hines Boulevard, Dallas, TX 75390-8551, USA
Daniel B Hardy - UT Southwestern Medical Center, Department of Biochemistry, 5323 Harry Hines Boulevard, Dallas, TX 75390-9038, USA
Raheela Ashfaq - UT Southwestern Medical Center, Department of Pathology, 5323 Harry Hines Boulevard, Dallas, TX 75390-9073, USA
Carole R Mendelson - UT Southwestern Medical Center, Department of Biochemistry, 5323 Harry Hines Boulevard, Dallas, TX 75390-9038, USA
Resource Type: Journal article
Publication Details: Cancer Letters, Vol.258(2), pp.253-261
Publisher: Elsevier Ireland Ltd
DOI: 10.1016/j.canlet.2007.09.011
PMID: 17950525
ISSN: 0304-3835
eISSN: 1872-7980
Language: English
Date published: 2007
Academic Unit: Preventive and Community Dentistry; Biostatistics; Dental Research
Record Identifier: 9983917689902771

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