Journal article
Progesterone: the ultimate endometrial tumor suppressor
Trends in endocrinology and metabolism, Vol.22(4), pp.145-152
04/2011
DOI: 10.1016/j.tem.2011.01.005
PMCID: PMC4062362
PMID: 21353793
Abstract
The uterine endometrium is exquisitely sensitive to steroid hormones that act through well-described nuclear receptors. Estrogen drives epithelial proliferation, and progesterone inhibits growth and causes cell differentiation. The importance of progesterone as a key inhibitor of carcinogenesis is reflected by the observation that women who ovulate and produce progesterone almost never get endometrial cancer. In this review we describe seminal research findings that define progesterone as the major endometrial tumor suppressor. We discuss the genes and diverse signaling pathways that are controlled by progesterone through progesterone receptors (PRs) and also the multiple factors that regulate progesterone/PR activity. By defining these progesterone-regulated factors and pathways we identify the principal therapeutic opportunities to control the growth of endometrial cancer.
Details
- Title: Subtitle
- Progesterone: the ultimate endometrial tumor suppressor
- Creators
- Shujie Yang - Department of Obstetrics & Gynecology and Holden Comprehensive Cancer Center,The University of Iowa, Iowa City, Iowa 52242, USAKristina W ThielKimberly K Leslie
- Resource Type
- Journal article
- Publication Details
- Trends in endocrinology and metabolism, Vol.22(4), pp.145-152
- DOI
- 10.1016/j.tem.2011.01.005
- PMID
- 21353793
- PMCID
- PMC4062362
- NLM abbreviation
- Trends Endocrinol Metab
- ISSN
- 1043-2760
- eISSN
- 1879-3061
- Publisher
- United States
- Grant note
- R01 CA099908 / NCI NIH HHS CA27469 / NCI NIH HHS U10 CA027469 / NCI NIH HHS CA99908 / NCI NIH HHS
- Language
- English
- Date published
- 04/2011
- Academic Unit
- Pathology; Obstetrics and Gynecology
- Record Identifier
- 9983930276902771
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