Journal article
Prognosis of Minimally Invasive Carcinoma Arising in Mucinous Cystic Neoplasms of the Pancreas
The American journal of surgical pathology, Vol.37(4), pp.601-605
04/2013
DOI: 10.1097/PAS.0b013e318273f3b0
PMCID: PMC3596434
PMID: 23388125
Abstract
While patients with surgically resected non-invasive mucinous cystic neoplasms (MCNs) of the pancreas are cured, the behavior of surgically resected minimally invasive adenocarcinomas arising in MCN has not been well established. We report 16 surgically resected MCNs with minimal invasion defined as unifocal or multifocal microscopic invasive adenocarcinoma confined to the ovarian stroma of the MCN without capsular or pancreatic parenchymal invasion. Pathological findings were correlated with patient demographics, type of surgery, and long-term follow-up. Our study included 15 females and 1 male ranging in age from 25–66 years. The patients were followed for a mean of 48.6 months (range 12–148 months). The MCNs ranged in size from 3.5–25 cm and were all located in the body/tail of the gland. Lymphovascular invasion was not identified in any of the cases and all lymph nodes were negative for tumor. Ten neoplasms had unifocal invasion, while 6 had multifocal invasion. Twelve of the neoplasms were partially submitted for microscopic examination while 4 were submitted entirely. Only one of the 16 minimally invasive MCNs recurred, and that tumor had been minimally sampled pathologically. Our study demonstrates that the majority of patients with minimally invasive adenocarcinoma arising in MCN are cured by surgery, particularly if the neoplasms are completely examined histologically.
Details
- Title: Subtitle
- Prognosis of Minimally Invasive Carcinoma Arising in Mucinous Cystic Neoplasms of the Pancreas
- Creators
- Gloria H Lewis - Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MDHuamin Wang - Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TXAndrew M Bellizzi - Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IAAlison P Klein - Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MDFrederic B Askin - Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MDLauren Ende Schwartz - Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PARichard D Schulick - Department of Surgery, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MDChristopher L Wolfgang - Department of Surgery, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MDJohn L Cameron - Department of Surgery, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MDEileen M O’Reilly - Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NYKenneth H Yu - Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NYRalph H Hruban - Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD
- Resource Type
- Journal article
- Publication Details
- The American journal of surgical pathology, Vol.37(4), pp.601-605
- DOI
- 10.1097/PAS.0b013e318273f3b0
- PMID
- 23388125
- PMCID
- PMC3596434
- NLM abbreviation
- Am J Surg Pathol
- ISSN
- 0147-5185
- eISSN
- 1532-0979
- Grant note
- P50 CA062924 || CA / National Cancer Institute : NCI
- Language
- English
- Date published
- 04/2013
- Academic Unit
- Pathology
- Record Identifier
- 9984047864902771
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