Journal article
Prognostic Implications of Ambulatory N-Terminal Pro-B-Type Natriuretic Peptide Changes in Patients with Continuous-Flow Left Ventricular Assist Devices
ASAIO journal (1992), Vol.68(4), pp.524-530
04/01/2022
DOI: 10.1097/MAT.0000000000001524
PMID: 34352812
Abstract
Data regarding the role of N-terminal Pro-B-type natriuretic peptide (NT-pro BNP) in patients with a continuous-flow left ventricular assist device (CFLVAD) is scarce. To evaluate the prognostic implications of measuring both absolute values and changes in NT-pro BNP concentrations in ambulatory patients with a CFLVAD, we performed a retrospective study of 168 consecutive patients who had an LVAD implantation at our institution and survived beyond their index hospitalization. Of these, 127 patients (56.2 ± 12.5 years, 21.2% female) had NT-pro BNP measured at 1 and 3 months postdischarge in ambulatory settings. Compared to the NT-pro BNP concentration at 1 month, 94 patients (74%) had a decline, and 33 patients (26%) had an increase in concentrations, from their 1 month baseline. After a median follow-up of 17 months, a total of 53 (41.7%) adverse events occurred. Of these, 37 (69.8%) were heart failure (HF) hospitalizations, and 16 (30.2%) were deaths. For each 1,000 unit increase in NT-pro BNP concentration at 3 months, there was a 17% increase in the risk of HF hospitalization or death (hazard ratio [HR] = 1.17, 95% confidence interval [CI] = 1.04-1.32, p = 0.007). Conversely, each 1000 unit decline during the same time, was associated with an 11% decrease in the risk of HF hospitalization or death (HR = 0.89, 95% CI = 0.77-0.98, p = 0.04). In conclusion, in patients with a CFLAD, an increase in NT-pro BNP concentration from 1 to 3 months is associated with an increased risk of HF hospitalization and death. In contrast, a decline is associated with a reduction in the risk of HF hospitalization and death.
Details
- Title: Subtitle
- Prognostic Implications of Ambulatory N-Terminal Pro-B-Type Natriuretic Peptide Changes in Patients with Continuous-Flow Left Ventricular Assist Devices
- Creators
- Abbas Ali - University of IowaEmmanuel Akintoye - From the Department of Medicine, University of Iowa Health Care, Carver College of Medicine, Iowa, IowaErnesto Ruiz Duque - From the Department of Medicine, University of Iowa Health Care, Carver College of Medicine, Iowa, IowaRupesh Kshetri - University of IowaSuchith Shetty - University of IowaUmesh C Sharma - Department of Medicine, University at Buffalo, Jacobs School of Medicine and Biomedical Sciences, Buffalo, New YorkCarol M Johnson - From the Department of Medicine, University of Iowa Health Care, Carver College of Medicine, Iowa, IowaAnthony L Panos - Department of Surgery, University of Iowa Health Care, Carver College of Medicine, Iowa, IowaAlexandros Briasoulis - University of IowaPaulino Alvarez - University of Iowa
- Resource Type
- Journal article
- Publication Details
- ASAIO journal (1992), Vol.68(4), pp.524-530
- DOI
- 10.1097/MAT.0000000000001524
- PMID
- 34352812
- ISSN
- 1058-2916
- eISSN
- 1538-943X
- Language
- English
- Date published
- 04/01/2022
- Academic Unit
- Cardiovascular Medicine; General Internal Medicine; Cardiothoracic Surgery; Internal Medicine
- Record Identifier
- 9984322818802771
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