Prognostic Role of Combined EGFR and Tumor-Infiltrating Lymphocytes in Oral Squamous Cell Carcinoma

Wattawan Wongpattaraworakul; Katherine N. Gibson-Corley; Allen Choi; Marisa R. Buchakjian; Emily A. Lanzel; Anand Rajan KD; Andrean L. Simons

doi:10.3389/fonc.2022.885236

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Prognostic Role of Combined EGFR and Tumor-Infiltrating Lymphocytes in Oral Squamous Cell Carcinoma

Journal article

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Prognostic Role of Combined EGFR and Tumor-Infiltrating Lymphocytes in Oral Squamous Cell Carcinoma

Wattawan Wongpattaraworakul, Katherine N. Gibson-Corley, Allen Choi, Marisa R. Buchakjian, Emily A. Lanzel, Anand Rajan KD and Andrean L. Simons

Frontiers in oncology, Vol.12, 885236

07/01/2022

DOI: 10.3389/fonc.2022.885236

PMCID: PMC9357911

PMID: 35957892

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Abstract

BackgroundEpidermal growth factor receptor (EGFR) is well known as a general prognostic biomarker for head and neck tumors, however the specific prognostic value of EGFR in oral squamous cell carcinoma (OSCC) is controversial. Recently, the presence of tumor-infiltrating T cells has been associated with significant survival advantages in a variety of disease sites. The present study will determine if the inclusion of T cell specific markers (CD3, CD4 and CD8) would enhance the prognostic value of EGFR in OSCCs.MethodsTissue microarrays containing 146 OSCC cases were analyzed for EGFR, CD3, CD4 and CD8 expression using immunohistochemical staining. EGFR and T cell expression scores were correlated with clinicopathological parameters and survival outcomes.ResultsResults showed that EGFR expression had no impact on overall survival (OS), but EGFR-positive (EGFR+) OSCC patients demonstrated significantly worse progression free survival (PFS) compared to EGFR-negative (EGFR-) patients. Patients with CD3, CD4 and CD8-positive tumors had significantly better OS compared to CD3, CD4 and CD8-negative patients respectively, but no impact on PFS. Combined EGFR+/CD3+ expression was associated with cases with no nodal involvement and significantly more favorable OS compared to EGFR+/CD3- expression. CD3 expression had no impact on OS or PFS in EGFR- patients. Combinations of EGFR/CD8 and EGFR/CD4 expression showed no significant differences in OS or PFS among the expression groups.ConclusionAltogether these results suggest that the expression of CD3+ tumor-infiltrating T cells can enhance the prognostic value of EGFR expression and warrants further investigation as prognostic biomarkers for OSCC.

biomarker

CD3

EGFR

microarray

OSCC

TIL

Details

Title: Subtitle: Prognostic Role of Combined EGFR and Tumor-Infiltrating Lymphocytes in Oral Squamous Cell Carcinoma
Creators: Wattawan Wongpattaraworakul - University of Iowa
Katherine N. Gibson-Corley - Vanderbilt University Medical Center
Allen Choi - University of Iowa
Marisa R. Buchakjian - University of Iowa
Emily A. Lanzel - University of Iowa
Anand Rajan KD - University of Iowa
Andrean L. Simons - University of Iowa
Resource Type: Journal article
Publication Details: Frontiers in oncology, Vol.12, 885236
DOI: 10.3389/fonc.2022.885236
PMID: 35957892
PMCID: PMC9357911
NLM abbreviation: Front Oncol
eISSN: 2234-943X
Publisher: Frontiers Media S.A
Grant note: DOI: 10.13039/100000738, name: U.S. Department of Veterans Affairs
Language: English
Date published: 07/01/2022
Academic Unit: Oral Pathology, Radiology and Medicine; The University of Iowa Institute for Vision Research; Pathology; Pharmaceutical Sciences and Experimental Therapeutics; Surgery; Radiation Oncology; Otolaryngology
Record Identifier: 9984277455202771

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