Journal article
Prognostic Significance of Large Airway Dimensions on Computed Tomography in the General Population The Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study
ANNALS OF THE AMERICAN THORACIC SOCIETY, Vol.15(6), pp.718-727
06/01/2018
DOI: 10.1513/AnnalsATS.201710-820OC
PMCID: PMC6137677
PMID: 29529382
Abstract
Rationale: Large airway dimensions on computed tomography (CT) have been associated with lung function, symptoms, and exacerbations in chronic obstructive pulmonary disease (COPD), as well as with symptoms in smokers with preserved spirometry. Their prognostic significance in persons without lung disease remains undefined.
Objectives: To examine associations between large airway dimensions on CT and respiratory outcomes in a population-based cohort of adults without prevalent lung disease.
Methods: The Multi-Ethnic Study of Atherosclerosis recruited participants ages 45-84 years without cardiovascular disease in 2000-2002; we excluded participants with prevalent chronic lower respiratory disease (CLRD). Spirometry was measured in 2004-2006 and 2010-2012. CLRD hospitalizations and deaths were classified by validated criteria through 2014. The average wall thickness for a hypothetical airway of 10-mm lumen perimeter on CT (Pi10) was calculated using measures of airway wall thickness and lumen diameter. Models were adjusted for age, sex, principal components of ancestry, body mass index, smoking, pack-years, scanner, percent emphysema, genetic risk score, and initial forced expiratory volume in 1 second (FEV1) percent predicted.
Results: Greater Pi10 was associated with 9% faster FEV1 decline (95% confidence interval [CI], 2 to 15%; P = 0.012) and increased incident COPD (odds ratio, 2.22; 95% CI, 1.43-3.45; P = 0.0004) per standard deviation among 1,830 participants. Over 78,147 person-years, higher Pi10 was associated with a 57% higher risk of first CLRD hospitalization or mortality (P = 0.0496) per standard deviation. Of Pi10's component measures, both greater airway wall thickness and narrower lumen predicted incident COPD and CLRD clinical events.
Conclusions: In adults without CLRD, large airway dimensions on CT were prospectively associated with accelerated lung function decline and increased risks of COPD and CLRD hospitalization and mortality.
Details
- Title: Subtitle
- Prognostic Significance of Large Airway Dimensions on Computed Tomography in the General Population The Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study
- Creators
- Elizabeth C. Oelsner - Columbia UniversityBenjamin M. Smith - McGill UniversityEric A. Hoffman - University of IowaRavi Kalhan - Northwestern UniversityKathleen M. Donohue - Columbia UniversityJoel D. Kaufman - University of WashingtonJennifer N. Nguyen - University of VirginiaAni W. Manichaikul - University of VirginiaJerome Rotter - University of California, Los AngelesErin D. Michos - Johns Hopkins UniversityDavid R. Jacobs - University of MinnesotaGregory L. Burke - Wake Forest UniversityAaron R. Folsom - University of MinnesotaJoseph E. Schwartz - Columbia UniversityKarol Watson - University of California, Los AngelesR. Graham Barr - Columbia University
- Resource Type
- Journal article
- Publication Details
- ANNALS OF THE AMERICAN THORACIC SOCIETY, Vol.15(6), pp.718-727
- Publisher
- Amer Thoracic Soc
- DOI
- 10.1513/AnnalsATS.201710-820OC
- PMID
- 29529382
- PMCID
- PMC6137677
- ISSN
- 1546-3222
- eISSN
- 2325-6621
- Number of pages
- 10
- Grant note
- UL1 RR025005 / NCRR NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) UL1TR000040 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) UL1RR025005 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) P30 ES005605; P30 ES009089 / NIEHS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) R21 HL129924; N01HC95159; N01HC95168; R01 HL093081; R01 HL112986; N01HC95163; N01HC95166; K23 HL130627; N01HC95160; N01HC95169; R01 HL130506; N01HC95167; R01 HL075476; N01HC95161; N01HC95165; N01HC95162; N01HC95164; R01 HL077612 / NHLBI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) R21HL129924 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) UL1 TR000040 / NCATS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) P30ES009089 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS)
- Language
- English
- Date published
- 06/01/2018
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
- Record Identifier
- 9984318719902771
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