Prognostic effect of the variable course of alcoholism on the 10-year course of depression

T I Mueller; P W Lavori; M B Keller; A Swartz; M Warshaw; D Hasin; W Coryell; J Endicott; J Rice; H Akiskal

doi:10.1176/ajp.151.5.701

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Prognostic effect of the variable course of alcoholism on the 10-year course of depression

Journal article

Peer reviewed

Prognostic effect of the variable course of alcoholism on the 10-year course of depression

T I Mueller, P W Lavori, M B Keller, A Swartz, M Warshaw, D Hasin, W Coryell, J Endicott, J Rice and H Akiskal

The American journal of psychiatry, Vol.151(5), pp.701-706

05/1994

DOI: 10.1176/ajp.151.5.701

PMID: 8166311

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Abstract

The purpose of this study was to examine the predictive effect of the clinical activity of patients' alcohol use on the course of major depressive disorder. One hundred seventy-six probands with Research Diagnostic Criteria (RDC) diagnoses of both major depressive disorder and alcoholism were compared to 412 probands with major depressive disorder only by using 10 years of short-interval, prospective follow-up data collected as part of the National Institute of Mental Health Collaborative Depression Study. The course of depression was examined by using intensity analysis to represent transitions between states of major depressive disorder. The effect of patients' RDC alcoholism status on the long-term course of major depressive disorder was examined by stratifying the analyses by three levels of alcoholism--never alcoholic, not meeting criteria for current alcoholism, and current alcoholism. Depressed probands who were either never alcoholic or currently nonactive alcoholic had twice the likelihood of recovery from major depressive disorder than did actively alcoholic depressed probands. The three levels of alcoholism did not differentially predict recurrence of major depressive disorder. These findings provide long-term, empirically derived evidence for the deleterious effect of current alcoholism on recovery from depression. The lack of a differential effect of the three levels of alcoholism on recurrence of major depressive disorder suggests that other factors may have greater predictive value.

Severity of Illness Index

Recurrence

Prognosis

Prospective Studies

Follow-Up Studies

Comorbidity

Humans

Depressive Disorder - diagnosis

Income

Male

Alcoholism - classification

Alcoholism - diagnosis

Marital Status

Alcoholism - epidemiology

Psychiatric Status Rating Scales

Survival Analysis

Adult

Female

Depressive Disorder - epidemiology

Details

Title: Subtitle: Prognostic effect of the variable course of alcoholism on the 10-year course of depression
Creators: T I Mueller - Alcohol and Drug Treatment Services, Butler Hospital, Providence, RI 02906
P W Lavori
M B Keller
A Swartz
M Warshaw
D Hasin
W Coryell
J Endicott
J Rice
H Akiskal
Resource Type: Journal article
Publication Details: The American journal of psychiatry, Vol.151(5), pp.701-706
Publisher: United States
DOI: 10.1176/ajp.151.5.701
PMID: 8166311
ISSN: 0002-953X
eISSN: 1535-7228
Grant note: NIMH MH-25478 / NIMH NIH HHS R01 MH025478 / NIMH NIH HHS
Language: English
Date published: 05/1994
Academic Unit: Psychiatry
Record Identifier: 9984004091202771

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