Prognostic factors for survival in patients with high-grade osteosarcoma using the Surveillance, Epidemiology, and End Results (SEER) Program database

Kyle R Duchman; Yubo Gao; Benjamin J Miller

doi:10.1016/j.canep.2015.05.001

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Prognostic factors for survival in patients with high-grade osteosarcoma using the Surveillance, Epidemiology, and End Results (SEER) Program database

Journal article

Peer reviewed

Prognostic factors for survival in patients with high-grade osteosarcoma using the Surveillance, Epidemiology, and End Results (SEER) Program database

Kyle R Duchman, Yubo Gao and Benjamin J Miller

Cancer epidemiology, Vol.39(4), pp.593-599

08/2015

DOI: 10.1016/j.canep.2015.05.001

PMID: 26002013

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Abstract

The current study aims to determine cause-specific survival in patients with high-grade osteosarcoma while reporting risk factors for decreased survival out to 10 years. The Surveillance, Epidemiology, and End Results (SEER) Program database was used to identify all patients diagnosed with high-grade osteosarcoma from 1991 to 2010. Patient, tumor, and county-level socioeconomic measures were analyzed to determine prognostic factors for survival. Cause-specific 10-year survival for patients with local/regional disease at the time of diagnosis was 65.8%, compared to 24.0% for patients with metastatic disease. Multivariate analysis revealed metastatic disease at presentation, age≥60 years, male sex, axial location, and size≥10cm as independent risk factors for decreased cause-specific survival at 10 years. Patients with the lowest socioeconomic status had a disproportionate frequency of metastatic disease and large tumors at presentation as compared to more affluent patients. Patients with high-grade osteosarcoma have decreased cause-specific survival at 10 years when metastatic at diagnosis, patient age≥60 years, male sex, axial tumor location, and tumors measuring≥10cm. Patients living in low socioeconomic counties present more frequently with metastatic disease and large tumors. Public health efforts should focus on identifying patients with osteosarcoma prior to metastasis.

Bone Neoplasms - mortality

Multivariate Analysis

Osteosarcoma - mortality

SEER Program

Prognosis

Humans

Middle Aged

Risk Factors

Male

Social Class

Neoplasm Grading

Adult

Female

Aged

Databases, Factual

Details

Title: Subtitle: Prognostic factors for survival in patients with high-grade osteosarcoma using the Surveillance, Epidemiology, and End Results (SEER) Program database
Creators: Kyle R Duchman - Department of Orthopaedics and Rehabilitation, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, 01015 JPP, Iowa City, IA 52242, USA. Electronic address: kyle-duchman@uiowa.edu
Yubo Gao - Department of Orthopaedics and Rehabilitation, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, 01015 JPP, Iowa City, IA 52242, USA. Electronic address: yubo-gao@uiowa.edu
Benjamin J Miller - Department of Orthopaedics and Rehabilitation, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, 01015 JPP, Iowa City, IA 52242, USA. Electronic address: benjamin-j-miller@uiowa.edu
Resource Type: Journal article
Publication Details: Cancer epidemiology, Vol.39(4), pp.593-599
DOI: 10.1016/j.canep.2015.05.001
PMID: 26002013
NLM abbreviation: Cancer Epidemiol
ISSN: 1877-7821
eISSN: 1877-783X
Publisher: Netherlands
Grant note: DP2 OD007483 / NIH HHS
Language: English
Date published: 08/2015
Academic Unit: Orthopedics and Rehabilitation; Internal Medicine
Record Identifier: 9984040002902771

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