Journal article
Prognostic impact and risk factors of cancer-associated thrombosis events in stage-IV cancer patients treated with immune checkpoint inhibitors
European journal of haematology, Vol.106(5), pp.682-688
05/01/2021
DOI: 10.1111/ejh.13598
PMID: 33565130
Abstract
Background: Cancer-associated thrombosis (CAT) is a major cause of mortality in cancer patients. Immune checkpoint inhibitors (ICIs) have been associated with multiple side effects including CAT. The aim of this study is to investigate risk factors and prognostic impact associated with CAT events during ICIs treatment.
Methods: This is a multi-center retrospective study that included stage IV cancer patients treated with ICIs.
Results: We identified 552 cancer patients treated with ICIs. During follow-up time, 58 (10.5%) patients developed 67 venous thromboembolism (VTE) events while on ICIs. Anticoagulation use at the time of ICIs treatment start was associated with significantly higher VTE incidence rate (IRR: 2.23). No significant difference in VTE IRR was observed depending on response to ICIs treatment, aspirin use, or Khorana VTE risk score. Melanoma as primary cancer, Khorana score, ECOG status, and anemia at baseline were able to predict mortality.
Conclusions: The incidence of CAT in stage-IV cancer patients treated with ICIs was higher in our study compared to previous reports. Control group of patients who did not receive ICIs is needed for better identification of CAT risk factors. Khorana score was a good predictor of mortality but not CAT risk and needs to be further validated in a homogenous group of patients.
Details
- Title: Subtitle
- Prognostic impact and risk factors of cancer-associated thrombosis events in stage-IV cancer patients treated with immune checkpoint inhibitors
- Creators
- Tariq Kewan - Cleveland ClinicTaeyeong Ko - Cleveland ClinicMonica Flores - Cleveland ClinicYacoub Sallam - Cleveland ClinicAbdo Haddad - Cleveland ClinicHamed Daw - Cleveland Clinic
- Resource Type
- Journal article
- Publication Details
- European journal of haematology, Vol.106(5), pp.682-688
- DOI
- 10.1111/ejh.13598
- PMID
- 33565130
- NLM abbreviation
- Eur J Haematol
- ISSN
- 0902-4441
- eISSN
- 1600-0609
- Publisher
- Wiley
- Number of pages
- 7
- Language
- English
- Date published
- 05/01/2021
- Academic Unit
- General Internal Medicine; Internal Medicine
- Record Identifier
- 9984692640702771
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