Journal article
Prognostic impact of acute pulmonary triggers in patients with takotsubo syndrome: new insights from the International Takotsubo Registry
ESC Heart Failure, Vol.8(3), pp.1924-1932
06/01/2021
DOI: 10.1002/ehf2.13165
PMCID: PMC8120351
PMID: 33713566
Abstract
AIMS
Acute pulmonary disorders are known physical triggers of takotsubo syndrome (TTS). This study aimed to investigate prevalence of acute pulmonary triggers in patients with TTS and their impact on outcomes.
METHODS AND RESULTS
Patients with TTS were enrolled from the International Takotsubo Registry and screened for triggering factors and comorbidities. Patients were categorized into three groups (acute pulmonary trigger, chronic lung disease, and no lung disease) to compare clinical characteristics and outcomes. Of the 1670 included patients with TTS, 123 (7%) were identified with an acute pulmonary trigger, and 194 (12%) had a known history of chronic lung disease. The incidence of cardiogenic shock was highest in patients with an acute pulmonary trigger compared with those with chronic lung disease or without lung disease (17% vs. 10% vs. 9%, P = 0.017). In-hospital mortality was also higher in patients with an acute pulmonary trigger than in the other two groups, although not significantly (5.7% vs. 1.5% vs. 4.2%, P = 0.13). Survival analysis demonstrated that patients with an acute pulmonary trigger had the worst long-term outcome (P = 0.002). The presence of an acute pulmonary trigger was independently associated with worse long-term mortality (hazard ratio 2.12, 95% confidence interval 1.33-3.38; P = 0.002).
CONCLUSIONS
The present study demonstrates that TTS is related to acute pulmonary triggers in 7% of all TTS patients, which accounts for 21% of patients with physical triggers. The presence of acute pulmonary trigger is associated with a severe in-hospital course and a worse long-term outcome.
Details
- Title: Subtitle
- Prognostic impact of acute pulmonary triggers in patients with takotsubo syndrome: new insights from the International Takotsubo Registry
- Creators
- Ken KatoVictoria L CammannL Christian NappKonrad A SzawanJozef MicekSara DreidingRena A LevinsonVanya PetkovaMichael WürdingerAlexandru PatrascuRafael SumalinogSebastiano GiliChristian F ClarenbachMalcolm KohlerKan Liu - University of Iowa, Internal MedicineThomas F LüscherFrank RuschitzkaJelena R GhadriChristian Templin
- Resource Type
- Journal article
- Publication Details
- ESC Heart Failure, Vol.8(3), pp.1924-1932
- Publisher
- Wiley Open Access
- DOI
- 10.1002/ehf2.13165
- PMID
- 33713566
- PMCID
- PMC8120351
- ISSN
- 2055-5822
- Grant note
- DOI: 10.13039/501100007601, name: Horizon 2020, award: ID777204; DOI: 10.13039/501100004362, name: Schweizerische Herzstiftung
- Language
- English
- Date published
- 06/01/2021
- Academic Unit
- Radiology; Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984318704902771
Metrics
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