Prognostic role of serum high mobility group box 1 concentration in cardiac surgery

Namo Kim; Sak Lee; Jeong-Rim Lee; Young-Lan Kwak; Ji-Hae Jun; Jae-Kwang Shim

doi:10.1038/s41598-020-63051-2

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Prognostic role of serum high mobility group box 1 concentration in cardiac surgery

Journal article

Peer reviewed

Prognostic role of serum high mobility group box 1 concentration in cardiac surgery

Namo Kim, Sak Lee, Jeong-Rim Lee, Young-Lan Kwak, Ji-Hae Jun and Jae-Kwang Shim

Scientific reports, Vol.10(1), pp.6293-6293

04/14/2020

DOI: 10.1038/s41598-020-63051-2

PMCID: PMC7156763

PMID: 32286371

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Abstract

Outcomes of cardiac surgery are influenced by systemic inflammation. High mobility group box 1 (HMGB1), a pivotal inflammatory mediator, plays a potential role as a prognostic biomarker in cardiovascular disease. The aim of this prospective, observational study was to investigate the relationship between serum HMGB1 concentrations and composite of morbidity endpoints in cardiac surgery. Arterial blood samples for HMGB1 measurement were collected from 250 patients after anaesthetic induction (baseline) and 1 h after weaning from cardiopulmonary bypass (post-CPB). The incidence of composite of morbidity endpoints (death, myocardial infarction, stroke, renal failure and prolonged ventilator care) was compared in relation to the tertile distribution of serum HMGB1 concentrations. The incidence of composite of morbidity endpoints was significantly different with respect to the tertile distribution of post-CPB HMGB1 concentrations (p = 0.005) only, and not to the baseline. Multivariable analysis revealed post-CPB HMGB1 concentration (OR, 1.072; p = 0.044), pre-operative creatinine and duration of CPB as independent risk factors of adverse outcome. Accounting for its prominent role in mediating sterile inflammation and its relation to detrimental outcome, HMGB1 measured 1 h after weaning from CPB would serve as a useful biomarker for accurate risk stratification in cardiac surgical patients and may guide tailored anti-inflammatory therapy.

Aged

Biomarkers - blood

Cardiac Surgical Procedures - adverse effects

Cardiac Surgical Procedures - mortality

Cardiopulmonary Bypass - adverse effects

Cardiopulmonary Bypass - mortality

Female

HMGB1 Protein - blood

Humans

Inflammation - etiology

Male

Middle Aged

Prognosis

Prospective Studies

Details

Title: Subtitle: Prognostic role of serum high mobility group box 1 concentration in cardiac surgery
Creators: Namo Kim - Yonsei University
Sak Lee - Yonsei University
Jeong-Rim Lee - Yonsei University
Young-Lan Kwak - Yonsei University
Ji-Hae Jun - Yonsei University
Jae-Kwang Shim - Yonsei University
Resource Type: Journal article
Publication Details: Scientific reports, Vol.10(1), pp.6293-6293
DOI: 10.1038/s41598-020-63051-2
PMID: 32286371
PMCID: PMC7156763
NLM abbreviation: Sci Rep
ISSN: 2045-2322
eISSN: 2045-2322
Language: English
Date published: 04/14/2020
Academic Unit: Anesthesia
Record Identifier: 9984806504502771

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