Journal article
Prognostic role of tumor budding in breast cancer
World journal of experimental medicine, Vol.8(2), pp.12-17
09/07/2018
DOI: 10.5493/wjem.v8.i2.12
PMCID: PMC6134264
PMID: 30211020
Abstract
Tumor budding, defined as a small number of cancer cells observed in pathology sections detached from the main tumor mass, is a common phenomenon in cancer. It is suggested that cells in buds are in the process of actively moving away from the primary tumor in the first step of metastasis. Tumor budding has been observed in a variety of carcinomas and is best studied in colorectal cancers where it portends poor prognosis. More recently, tumor budding was found to be of prognostic significance in other cancers including breast cancer. Tumor budding in breast cancer is associated with other adverse pathologic factors, such as larger tumor size and lymphovascular invasion, but may have additional independent prognostic value. In the future, standardization of the quantification criteria for tumor budding may further aid in its adoption as a prognostic marker.
Details
- Title: Subtitle
- Prognostic role of tumor budding in breast cancer
- Creators
- Ioannis A Voutsadakis
- Resource Type
- Journal article
- Publication Details
- World journal of experimental medicine, Vol.8(2), pp.12-17
- DOI
- 10.5493/wjem.v8.i2.12
- PMID
- 30211020
- PMCID
- PMC6134264
- NLM abbreviation
- World J Exp Med
- ISSN
- 2220-315X
- eISSN
- 2220-315X
- Language
- English
- Date published
- 09/07/2018
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984808092402771
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