Journal article
Programming of Adult Cardiovascular Disease following Exposure to Late-Gestation Hyperglycemia
Neonatology (Basel, Switzerland), Vol.100(2), pp.198-205
08/2011
DOI: 10.1159/000324863
PMCID: PMC3085032
PMID: 21455011
Abstract
Background: In utero exposure to hyperglycemia is becoming increasingly prevalent as the number of women entering pregnancy with type II diabetes, or developing gestational diabetes, increases. Both animal studies and epidemiologic investigations have found cardiovascular abnormalities in adult offspring of hyperglycemic mothers (OHM).
Objective: We hypothesized that adult OHM would have abnormal cardiac function in vivo and increased susceptibility to ischemia.
Methods: Pregnant rats were made diabetic on day 12 of gestation. Serum glucose was monitored twice daily and insulin provided to maintain serum glucose at 200-400 mg/dl. Offspring were fostered to normal mothers after birth. Adult OHM were studied at 8-10 months of age with echocardiography to assess in vivo cardiac function and isolated hearts to determine the response to ischemia.
Results: Echocardiography found significant diastolic dysfunction in male OHM compared to male controls. In isolated hearts, baseline cardiac function and left ventricular compliance was significantly diminished in male OHM compared to controls. Ischemia caused a significant decline in heart function in controls and female OHM, while function in male OHM remained unchanged.
Conclusions: Adult male OHM demonstrate programmed cardiac dysfunction. Given the growing number of pregnancies complicated by hyperglycemia, additional assessment of cardiac function of adults born to diabetic mothers may be warranted.
Details
- Title: Subtitle
- Programming of Adult Cardiovascular Disease following Exposure to Late-Gestation Hyperglycemia
- Creators
- Melissa Agoudemos - Departments of Pediatrics, University of Iowa, Iowa City, Iowa, USABenjamin E Reinking - Departments of Pediatrics, University of Iowa, Iowa City, Iowa, USAStacia L Koppenhafer - Departments of Pediatrics, University of Iowa, Iowa City, Iowa, USAJeffrey L Segar - Departments of Pediatrics, University of Iowa, Iowa City, Iowa, USAThomas D Scholz - Departments of Pediatrics, University of Iowa, Iowa City, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- Neonatology (Basel, Switzerland), Vol.100(2), pp.198-205
- Publisher
- S. Karger AG
- DOI
- 10.1159/000324863
- PMID
- 21455011
- PMCID
- PMC3085032
- ISSN
- 1661-7800
- eISSN
- 1661-7819
- Language
- English
- Date published
- 08/2011
- Academic Unit
- Cardiology; Stead Family Department of Pediatrics; Hematology/Oncology; Fraternal Order of Eagles Diabetes Research Center; Child and Community Health
- Record Identifier
- 9984093371802771
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