Progress and Prospects: prospects of repeated pulmonary administration of viral vectors

P. L SINN; E. R BURNIGHT; P. B MCCRAY

doi:10.1038/gt.2009.87

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Progress and Prospects: prospects of repeated pulmonary administration of viral vectors

Journal article

Peer reviewed

Progress and Prospects: prospects of repeated pulmonary administration of viral vectors

P. L SINN, E. R BURNIGHT and P. B MCCRAY

Gene therapy, Vol.16(9), pp.1059-1065

2009

DOI: 10.1038/gt.2009.87

PMID: 19641533

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https://www.ncbi.nlm.nih.gov/pmc/articles/4376355View

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Abstract

Pulmonary gene therapy may ultimately cure diseases such as cystic fibrosis, α1-antitrypsin deficiency, lung cancer and pulmonary hypertension. Efficient expression of delivered genes in target cell types is essential for the achievement of this goal. To this end, re-administration of viral vectors may be required (1) to increase the percentage of transduced airway epithelial cells, (2) to direct gene transfer to individual lobes during successive delivery sessions or (3) to boost attenuated expression over time. Immune responses to viral proteins or viral-encoded proteins are the greatest barrier to repeated vector administration.

Biotechnology

Gene Therapy

Fundamental and applied biological sciences. Psychology

Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy

Health. Pharmaceutical industry

Industrial applications and implications. Economical aspects

Transfusions. Complications. Transfusion reactions. Cell and gene therapy

Applied cell therapy and gene therapy

Biological and medical sciences

Medical sciences

Details

Title: Subtitle: Progress and Prospects: prospects of repeated pulmonary administration of viral vectors
Creators: P. L SINN - Program in Gene Therapy, Department of Pediatrics, Carver College of Medicine, The University of Iowa, Iowa City, IA, United States
E. R BURNIGHT - Interdisciplinary Program in Genetics, Carver College of Medicine, The University of Iowa, Iowa City, IA, United States
P. B MCCRAY - Program in Gene Therapy, Department of Pediatrics, Carver College of Medicine, The University of Iowa, Iowa City, IA, United States
Resource Type: Journal article
Publication Details: Gene therapy, Vol.16(9), pp.1059-1065
DOI: 10.1038/gt.2009.87
PMID: 19641533
NLM abbreviation: Gene Ther
ISSN: 0969-7128
eISSN: 1476-5462
Publisher: Nature Publishing Group
Language: English
Date published: 2009
Academic Unit: Microbiology and Immunology; Pulmonary Medicine; Stead Family Department of Pediatrics; Internal Medicine; Ophthalmology and Visual Sciences
Record Identifier: 9984093337002771

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