Journal article
Progress in antifungal susceptibility testing of Candida spp. by use of Clinical and Laboratory Standards Institute broth microdilution methods, 2010 to 2012
Journal of clinical microbiology, Vol.50(9), pp.2846-2856
09/2012
DOI: 10.1128/JCM.00937-12
PMCID: PMC3421803
PMID: 22740712
Abstract
Antifungal susceptibility testing of Candida has been standardized and refined and now may play a useful role in managing Candida infections. Important new developments include validation of 24-h reading times for all antifungal agents and the establishment of species-specific epidemiological cutoff values (ECVs) for the systemically active antifungal agents and both common and uncommon species of Candida. The clinical breakpoints (CBPs) for fluconazole, voriconazole, and the echinocandins have been revised to provide species-specific interpretive criteria for the six most common species. The revised CBPs not only are predictive of clinical outcome but also provide a more sensitive means of identifying those strains with acquired or mutational resistance mechanisms. This brief review serves as an update on the new developments in the antifungal susceptibility testing of Candida spp. using Clinical and Laboratory Standards Institute (CLSI) broth microdilution (BMD) methods.
Details
- Title: Subtitle
- Progress in antifungal susceptibility testing of Candida spp. by use of Clinical and Laboratory Standards Institute broth microdilution methods, 2010 to 2012
- Creators
- M A Pfaller - JMI Laboratories, North Liberty, Iowa, USAD J Diekema
- Resource Type
- Journal article
- Publication Details
- Journal of clinical microbiology, Vol.50(9), pp.2846-2856
- Publisher
- United States
- DOI
- 10.1128/JCM.00937-12
- PMID
- 22740712
- PMCID
- PMC3421803
- ISSN
- 1098-660X
- eISSN
- 1098-660X
- Language
- English
- Date published
- 09/2012
- Academic Unit
- Infectious Diseases; Epidemiology; Pathology; Internal Medicine
- Record Identifier
- 9983986373402771
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