Progress on retinal image analysis for age related macular degeneration

Yogesan Kanagasingam; Alauddin Bhuiyan; Michael D Abràmoff; R. Theodore Smith; Leonard Goldschmidt; Tien Y Wong

doi:10.1016/j.preteyeres.2013.10.002

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Progress on retinal image analysis for age related macular degeneration

Journal article

Open access

Peer reviewed

Progress on retinal image analysis for age related macular degeneration

Yogesan Kanagasingam, Alauddin Bhuiyan, Michael D Abràmoff, R. Theodore Smith, Leonard Goldschmidt and Tien Y Wong

Progress in Retinal and Eye Research, Vol.38, pp.20-42

01/2014

DOI: 10.1016/j.preteyeres.2013.10.002

PMID: 24211245

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Abstract

Age-related macular degeneration (AMD) is the leading cause of vision loss in those over the age of 50 years in the developed countries. The number is expected to increase by ∼1.5 fold over the next ten years due to an increase in aging population. One of the main measures of AMD severity is the analysis of drusen, pigmentary abnormalities, geographic atrophy (GA) and choroidal neovascularization (CNV) from imaging based on color fundus photograph, optical coherence tomography (OCT) and other imaging modalities. Each of these imaging modalities has strengths and weaknesses for extracting individual AMD pathology and different imaging techniques are used in combination for capturing and/or quantification of different pathologies. Current dry AMD treatments cannot cure or reverse vision loss. However, the Age-Related Eye Disease Study (AREDS) showed that specific anti-oxidant vitamin supplementation reduces the risk of progression from intermediate stages (defined as the presence of either many medium-sized drusen or one or more large drusen) to late AMD which allows for preventative strategies in properly identified patients. Thus identification of people with early stage AMD is important to design and implement preventative strategies for late AMD, and determine their cost-effectiveness. A mass screening facility with teleophthalmology or telemedicine in combination with computer-aided analysis for large rural-based communities may identify more individuals suitable for early stage AMD prevention. In this review, we discuss different imaging modalities that are currently being considered or used for screening AMD. In addition, we look into various automated and semi-automated computer-aided grading systems and related retinal image analysis techniques for drusen, geographic atrophy and choroidal neovascularization detection and/or quantification for measurement of AMD severity using these imaging modalities. We also review the existing telemedicine studies which include diagnosis and management of AMD, and how automated disease grading could benefit telemedicine. As there is no treatment for dry AMD and only early intervention can prevent the late AMD, we emphasize mass screening through a telemedicine platform to enable early detection of AMD. We also provide a comparative study between the imaging modalities and identify potential study areas for further improvement and future research direction in automated AMD grading and screening.

Fundus photograph

Population screening

Optical coherence tomography

Automation and disease grading

Telemedicine

Expert system

Age related macular degeneration

Details

Title: Subtitle: Progress on retinal image analysis for age related macular degeneration
Creators: Yogesan Kanagasingam - Australian e-Health Research Centre, Commonwealth Scientific and Industrial Research Organization (CSIRO), 65 Brockway Road, Floreat, Underwood Avenue, WA 6014, Australia
Alauddin Bhuiyan - Australian e-Health Research Centre, Commonwealth Scientific and Industrial Research Organization (CSIRO), 65 Brockway Road, Floreat, Underwood Avenue, WA 6014, Australia
Michael D Abràmoff - Ophthalmology and Visual Sciences, Electrical and Computer Engineering, Biomedical Engineering, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
R. Theodore Smith - Retinal Image Analysis Laboratory, Department of Ophthalmology, NYU School of Medicine, NY, NY 10016, USA
Leonard Goldschmidt - VA Palo Alto Health Care Systems, 3801 Miranda Avenue, Palo Alto, CA 94304-1290, USA
Tien Y Wong - Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, 32 Gisborne Street, East Melbourne 3002, Australia
Resource Type: Journal article
Publication Details: Progress in Retinal and Eye Research, Vol.38, pp.20-42
DOI: 10.1016/j.preteyeres.2013.10.002
PMID: 24211245
NLM abbreviation: Prog Retin Eye Res
ISSN: 1350-9462
eISSN: 1873-1635
Publisher: Elsevier Ltd
Language: English
Date published: 01/2014
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Ophthalmology and Visual Sciences
Record Identifier: 9983806252702771

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