Journal article
Progression of cartilage damage and meniscal pathology over 30 months is associated with an increase in radiographic tibiofemoral joint space narrowing in persons with knee OA – the MOST study
Osteoarthritis and cartilage, Vol.22(10), pp.1743-1747
10/2014
DOI: 10.1016/j.joca.2014.07.008
PMID: 25278083
Abstract
To determine the association of MRI-assessed worsening of tibiofemoral cartilage damage, meniscal damage, meniscal extrusion, separately and together, with progression of radiographic joint space narrowing (JSN).
The Multicenter Osteoarthitis Study (MOST) Study is a cohort study of subjects with or at risk for knee osteoarthritis (OA). Knees with radiographic OA Kellgren–Lawrence grade 2 at baseline and with baseline and 30-month 1.0T MRIs were selected for reading using the WORMS system for cartilage damage, meniscal damage, and meniscal extrusion. The association of worsening of cartilage damage, meniscal damage, and/or meniscal extrusion with increases in the JSN was performed using logistic regression.
A total of 276 knees (one per subject) were included (women 68.5%, mean age 62.9 ± 7.8, mean body mass index (BMI) 30.2 ± 5.0). Worsening of each MRI feature was associated with any increase in JSN (P < 0.01). Worsening of cartilage damage was more frequently observed than worsening of meniscal damage and extrusion, and was significantly associated with both slow and fast progression of JSN. An increasing risk of JSN worsening was associated with increasing number of worsening MRI features (P for trend < 0.0001).
Worsening of tibiofemoral cartilage damage, meniscal damage, and meniscal extrusion are independent predictors of JSN progression in the same compartment. Worsening of cartilage damage is more frequently observed in JSN when compared to meniscal worsening. A strong cumulative effect on JSN progression is observed for worsening of more than one MRI feature.
Details
- Title: Subtitle
- Progression of cartilage damage and meniscal pathology over 30 months is associated with an increase in radiographic tibiofemoral joint space narrowing in persons with knee OA – the MOST study
- Creators
- M.D Crema - Department of Radiology, Quantitative Imaging Center, Boston University School of Medicine, Boston, MA, USAM.C Nevitt - Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA, USAA Guermazi - Department of Radiology, Quantitative Imaging Center, Boston University School of Medicine, Boston, MA, USAD.T Felson - Clinical Epidemiology Research Unit, Boston University School of Medicine, Boston, MA, USAK Wang - Boston UniversityJ.A Lynch - Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA, USAM.D Marra - Department of Radiology, Quantitative Imaging Center, Boston University School of Medicine, Boston, MA, USAJ Torner - University of Iowa, Iowa City, IA, USAC.E Lewis - University of Alabama, Birmingham, AL, USAF.W Roemer - Department of Radiology, Quantitative Imaging Center, Boston University School of Medicine, Boston, MA, USA
- Resource Type
- Journal article
- Publication Details
- Osteoarthritis and cartilage, Vol.22(10), pp.1743-1747
- DOI
- 10.1016/j.joca.2014.07.008
- PMID
- 25278083
- NLM abbreviation
- Osteoarthritis Cartilage
- ISSN
- 1063-4584
- eISSN
- 1522-9653
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 10/2014
- Academic Unit
- Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
- Record Identifier
- 9983995156002771
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