Journal article
Progression of coronary atherosclerosis quantified by analysis of 3-D reconstruction of left coronary arteries
Atherosclerosis, Vol.160(2), pp.483-493
02/01/2002
DOI: 10.1016/S0021-9150(01)00609-8
PMID: 11849675
Abstract
Objectives: Quantitative measurements on three-dimensional (3-D) reconstructed coronary trees permit accurate evaluation of vascular volumes, lengths and diameters. We applied this technique to investigate diffuse luminal narrowing in patients with the clinical manifestation of progressive atherosclerosis.
Methods: In 13 patients who presented repeatedly for coronary angioplasty (at least 4 years of invasive follow-up), left coronary arteries were reconstructed in 3-D from biplane coronary angiograms. Mean diameter, cross-sectional areas, total length, and volume were calculated for segments and branches. Five patients without coronary artery disease served as controls.
Results: Patients with progressive coronary atherosclerosis demonstrated a significant reduction of total vascular volumes, mean diameters and cross-sectional areas at the initial investigation when compared with controls. Progressive luminal shrinkage occurred during follow-up (−0.04±0.13 mm per year and per segmental diameter). The progress of luminal narrowing in patients with coronary artery disease is related to the number of coronary risk factors and the duration of follow-up.
Conclusion: Quantitative measurements on 3-D reconstructed coronary trees are a useful investigative tool for the assessment of progression of coronary atherosclerosis.
Details
- Title: Subtitle
- Progression of coronary atherosclerosis quantified by analysis of 3-D reconstruction of left coronary arteries
- Creators
- Ernst Wellnhofer - Deutsches Herzzentrum der CharitéAndreas Wahle - University of IowaEckart Fleck - Deutsches Herzzentrum der Charité
- Resource Type
- Journal article
- Publication Details
- Atherosclerosis, Vol.160(2), pp.483-493
- Publisher
- Elsevier Ireland Ltd
- DOI
- 10.1016/S0021-9150(01)00609-8
- PMID
- 11849675
- ISSN
- 0021-9150
- eISSN
- 1879-1484
- Language
- English
- Date published
- 02/01/2002
- Academic Unit
- Electrical and Computer Engineering; Radiation Oncology; The Iowa Institute for Biomedical Imaging
- Record Identifier
- 9984459626802771
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