Journal article
Progression of traumatic intracerebral hemorrhage: A prospective observational study
Journal of neurotrauma, Vol.25(6), pp.629-639
06/01/2008
DOI: 10.1089/neu.2007.0385
PMID: 18491950
Abstract
Preliminary evidence has shown that intracerebral hemorrhages, either spontaneous (sICH) or traumatic (tICH) often expand over time. An association between hemorrhage expansion and clinical outcomes has been described for sICH. The intent of this prospective, observational study was to characterize the temporal profile of hemorrhage progression, as measured by serial computed tomography (CT) scanning, with the aim of better understanding the natural course of hemorrhage progression in tICH. There was also a desire to document the baseline adverse event (AE) profile in this patient group. An important motive for performing this study was to set the stage for subsequent studies that will examine the role of a new systemic hemostatic agent in tICH. Subjects were enrolled if they had tICH lesions of at least 2 mL on a baseline CT scan obtained within 6 h of a head injury. CT scans were repeated at 24 and 72 h. Clinical outcomes and pre-defined AEs were documented. The data showed that 51% of the subjects demonstrated an increase in tICH volume, and that most of the increase occurred early. In addition, larger hematomas exhibited the greatest expansion. Thromboembolic complications were identified in 13% of subjects. This study demonstrates that tICH expansion between the baseline and 24-h CT scans occurred in approximately half of the subjects. The earlier after injury that the initial CT scan is obtained, the greater is the likelihood that the hematoma will expand on subsequent scans. The time frame during which hemorrhagic expansion occurs provides an opportunity for early intervention to limit a process with adverse prognostic implications.
Details
- Title: Subtitle
- Progression of traumatic intracerebral hemorrhage: A prospective observational study
- Creators
- Raj K. Narayan - University of CincinnatiAndrew I. R. Maas - University of AntwerpFranco Servadei - University of ParmaBrett E. Skolnick - Novo NordiskMichael N. Tillinger - Novo NordiskLawrence F. Marshall - University of California, San DiegoTraumatic Intracerebral Hemorrhage Study Group
- Contributors
- P Hitchon (Contributor) - University of Iowa, Neurosurgery
- Resource Type
- Journal article
- Publication Details
- Journal of neurotrauma, Vol.25(6), pp.629-639
- Publisher
- Mary Ann Liebert, Inc
- DOI
- 10.1089/neu.2007.0385
- PMID
- 18491950
- ISSN
- 0897-7151
- eISSN
- 1557-9042
- Number of pages
- 11
- Language
- English
- Date published
- 06/01/2008
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurosurgery
- Record Identifier
- 9984304030102771
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