Progression of vascular and neural dysfunction in sciatic nerves of Zucker diabetic fatty and Zucker rats

Christine L Oltman; Lawrence J Coppey; Jill S Gellett; Eric P Davidson; Donald D Lund; Mark A Yorek

doi:10.1152/ajpendo.00594.2004

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Progression of vascular and neural dysfunction in sciatic nerves of Zucker diabetic fatty and Zucker rats

Journal article

Peer reviewed

Progression of vascular and neural dysfunction in sciatic nerves of Zucker diabetic fatty and Zucker rats

Christine L Oltman, Lawrence J Coppey, Jill S Gellett, Eric P Davidson, Donald D Lund and Mark A Yorek

American journal of physiology: endocrinology and metabolism, Vol.289(1), pp.E113-122

07/2005

DOI: 10.1152/ajpendo.00594.2004

PMID: 15727946

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Abstract

We have examined the progression of vascular and neural deficits in Zucker rats, Zucker diabetic fatty (ZDF) diabetic rats, and age-matched lean ZDF rats from 8 to 40 wk of age. Both the ZDF diabetic and Zucker rats were glucose intolerant at 8 wk of age. The Zucker rats did not become hyperglycemic but were hyperinsulinemic through 32 wk of age. All ZDF diabetic rats became hyperglycemic by 8 wk of age. Through their life span, serum free fatty acids and triglycerides levels were significantly higher in Zucker and ZDF diabetic rats compared with age-matched lean ZDF rats. After 24 and 28 wk of age, endoneurial blood flow was significantly decreased in ZDF diabetic and Zucker rats. Motor nerve conduction velocity was significantly decreased after 12-14 wk of age in ZDF diabetic rats and at 32 wk of age in Zucker rats. ACh-mediated vascular relaxation of epineurial arterioles of the sciatic nerve was impaired after 8-10 wk of age in ZDF diabetic rats and after approximately 16 wk of age in Zucker rats. In contrast, vascular relaxation mediated by calcitonin gene-related peptide was impaired significantly after 28 wk of age in ZDF diabetic rats but not impaired in Zucker rats up to 40 wk of age. Markers of oxidative stress were differentially elevated in ZDF diabetic rats and Zucker rats. These data indicate that vascular and neural dysfunction develops in both Zucker and ZDF diabetic rats but at different rates, which may be the result of hyperglycemia.

Body Weight

Diabetic Neuropathies - etiology

Diabetic Angiopathies - etiology

Hyperglycemia - complications

Male

Diabetic Angiopathies - physiopathology

Metabolic Syndrome - physiopathology

Calcitonin Gene-Related Peptide - metabolism

Hyperglycemia - physiopathology

Hyperlipidemias - physiopathology

Diabetes Mellitus, Type 2 - complications

Hyperlipidemias - complications

Diabetic Neuropathies - physiopathology

Sciatic Neuropathy - etiology

Blood Glucose - analysis

Obesity - complications

Rats

Neural Conduction

Obesity - physiopathology

Disease Progression

Metabolic Syndrome - complications

Rats, Zucker

Insulin - metabolism

Animals

Diabetes Mellitus, Type 2 - physiopathology

Sciatic Neuropathy - physiopathology

Details

Title: Subtitle: Progression of vascular and neural dysfunction in sciatic nerves of Zucker diabetic fatty and Zucker rats
Creators: Christine L Oltman - Veteran Affairs Medical Center, Iowa City, IA 52246, USA
Lawrence J Coppey
Jill S Gellett
Eric P Davidson
Donald D Lund
Mark A Yorek
Resource Type: Journal article
Publication Details: American journal of physiology: endocrinology and metabolism, Vol.289(1), pp.E113-122
DOI: 10.1152/ajpendo.00594.2004
PMID: 15727946
ISSN: 0193-1849
eISSN: 1522-1555
Language: English
Date published: 07/2005
Academic Unit: Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine
Record Identifier: 9984094627202771

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