Journal article
Progressive aphasia in a patient with Pick's disease: a neuropsychological, radiologic, and anatomic study
Neurology, Vol.40(4), pp.620-626
04/1990
DOI: 10.1212/WNL.40.4.620
PMID: 2320235
Abstract
Although Pick's disease is generally considered as a dementia characterized by signs of frontal lobe dysfunction, it can present with selective language defects rather than with cognitive decline. In this study, we report prospective and serial clinical, neuropsychological, and neuroradiologic observations in a 59-year-old man whose prominent disturbance was in the retrieval and learning of names denoting concrete entities and actions. Postmortem study confirmed the diagnosis of Pick's disease and revealed that neuronal loss and gliosis were most prominent in left anterior temporal cortices. The findings are in keeping with evidence that the left anterior temporal cortices and interconnected hippocampal system are critically involved in the learning and retrieval of verbal lexical items. The evidence from this patient, along with similar evidence from the literature we reviewed, suggests that when patients present with a progressive aphasia characterized by anomia, Pick's disease should be considered as the probable diagnosis.
Details
- Title: Subtitle
- Progressive aphasia in a patient with Pick's disease: a neuropsychological, radiologic, and anatomic study
- Creators
- N R Graff-Radford - Department of Neurology, University of Iowa College of Medicine, Iowa CityA R DamasioB T HymanM N HartD TranelH DamasioG W Van HoesenK Rezai
- Resource Type
- Journal article
- Publication Details
- Neurology, Vol.40(4), pp.620-626
- DOI
- 10.1212/WNL.40.4.620
- PMID
- 2320235
- NLM abbreviation
- Neurology
- ISSN
- 0028-3878
- eISSN
- 1526-632X
- Publisher
- United States
- Grant note
- P01 NS19632 / NINDS NIH HHS
- Language
- English
- Date published
- 04/1990
- Academic Unit
- Neurology; Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984002418702771
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