Journal article
Progressive differentiation toward the long-lived plasma cell compartment in the bone marrow
The Journal of experimental medicine, Vol.220(2)
02/06/2023
DOI: 10.1084/jem.20221717
PMCID: PMC9754767
PMID: 36515679
Abstract
The longevity of plasma cells is dependent on their ability to access and reside in so-called niches that are predominantly located in the bone marrow. Here, by employing a traceable method to label recently generated plasma cells, we showed that homeostatic plasma cells in the bone marrow and spleen were continuously replenished by newly generated B220hiMHC-IIhi populations that progressively differentiated into B220loMHC-IIlo long-lived plasma cell (LLPC) populations. We also found that, in the bone marrow, germinal center (GC)-independent and GC-dependent plasma cells decayed similarly upon NP-CGG engagement, and both entered the B220loMHC-IIlo LLPC pool. Compared with NP+B220hiMHC-IIhi plasma cells, NP+B220loMHC-IIlo cells were more immobilized in the bone marrow niches and showed better survival potential. Thus, our results suggest that the adhesion status of bone marrow plasma cells is dynamically altered during their differentiation and is associated with provision of survival signals.
Details
- Title: Subtitle
- Progressive differentiation toward the long-lived plasma cell compartment in the bone marrow
- Creators
- Takuya Koike - The University of OsakaKentaro Fujii - The University of OsakaKohei Kometani - RIKEN Center for Integrative Medical SciencesNoah S Butler - Department of Microbiology and Immunology, The University of Iowa, Iowa City, IA, USAKenji Funakoshi - The University of OsakaShinya Yari - The University of OsakaJunichi Kikuta - Laboratory of Bioimaging and Drug Discovery, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, JapanMasaru Ishii - The University of OsakaTomohiro Kurosaki - The University of OsakaWataru Ise - The University of Osaka
- Resource Type
- Journal article
- Publication Details
- The Journal of experimental medicine, Vol.220(2)
- DOI
- 10.1084/jem.20221717
- PMID
- 36515679
- PMCID
- PMC9754767
- NLM abbreviation
- J Exp Med
- eISSN
- 1540-9538
- Grant note
- Nippon Foundation Uehara Memorial Foundation Naito Foundation JP22H00450 / Japan Society for the Promotion of Science KAKENHI SENSHIN Medical Research Foundation Daiichi Sankyo Foundation of Life Science JP22J00313 / Grand-in-Aid for JSPS Fellows JP20K16283 / Grand-in-Aid for Young Scientists Otsuka Pharmaceutical Co., Ltd.
- Language
- English
- Date published
- 02/06/2023
- Academic Unit
- Molecular Physiology and Biophysics; Microbiology and Immunology
- Record Identifier
- 9984339359902771
Metrics
31 Record Views