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Progressive differentiation toward the long-lived plasma cell compartment in the bone marrow
Journal article   Open access   Peer reviewed

Progressive differentiation toward the long-lived plasma cell compartment in the bone marrow

Takuya Koike, Kentaro Fujii, Kohei Kometani, Noah S Butler, Kenji Funakoshi, Shinya Yari, Junichi Kikuta, Masaru Ishii, Tomohiro Kurosaki and Wataru Ise
The Journal of experimental medicine, Vol.220(2)
02/06/2023
DOI: 10.1084/jem.20221717
PMCID: PMC9754767
PMID: 36515679
url
https://doi.org/10.1084/jem.20221717View
Published (Version of record) Open Access

Abstract

The longevity of plasma cells is dependent on their ability to access and reside in so-called niches that are predominantly located in the bone marrow. Here, by employing a traceable method to label recently generated plasma cells, we showed that homeostatic plasma cells in the bone marrow and spleen were continuously replenished by newly generated B220hiMHC-IIhi populations that progressively differentiated into B220loMHC-IIlo long-lived plasma cell (LLPC) populations. We also found that, in the bone marrow, germinal center (GC)-independent and GC-dependent plasma cells decayed similarly upon NP-CGG engagement, and both entered the B220loMHC-IIlo LLPC pool. Compared with NP+B220hiMHC-IIhi plasma cells, NP+B220loMHC-IIlo cells were more immobilized in the bone marrow niches and showed better survival potential. Thus, our results suggest that the adhesion status of bone marrow plasma cells is dynamically altered during their differentiation and is associated with provision of survival signals.
Bone Marrow Bone Marrow Cells Cell Differentiation Cell Survival Germinal Center Plasma Cells - metabolism

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