Journal article
Progressive inner retinal neurodegeneration in non-proliferative macular telangiectasia type 2
British journal of ophthalmology, Vol.109(3), pp.401-407
03/2025
DOI: 10.1136/bjo-2023-325115
PMCID: PMC11866295
PMID: 39288977
Abstract
Purpose Patients with non-proliferative macular telangiectasia type 2 (MacTel) have ganglion cell layer (GCL) and nerve fibre layer (NFL) loss, but it is unclear whether the thinning is progressive. We quantified the change in retinal layer thickness over time in MacTel with and without diabetes.MethodsIn this retrospective, multicentre, comparative case series, subjects with MacTel with at least two optical coherence tomographic (OCT) scans separated by >9 months OCTs were segmented using the Iowa Reference Algorithms. Mean NFL and GCL thickness was computed across the total area of the early treatment diabetic retinopathy study grid and for the inner temporal region to determine the rate of thinning over time. Mixed effects models were fit to each layer and region to determine retinal thinning for each sublayer over time.Results115 patients with MacTel were included; 57 patients (50%) had diabetes and 21 (18%) had a history of carbonic anhydrase inhibitor (CAI) treatment. MacTel patients with and without diabetes had similar rates of thinning. In patients without diabetes and untreated with CAIs, the temporal parafoveal NFL thinned at a rate of −0.25±0.09 µm/year (95% CI [−0.42 to –0.09]; p=0.003). The GCL in subfield 4 thinned faster in the eyes treated with CAI (−1.23±0.21 µm/year; 95% CI [−1.64 to –0.82]) than in untreated eyes (−0.19±0.16; 95% CI [−0.50, 0.11]; p<0.001), an effect also seen for the inner nuclear layer. Progressive outer retinal thinning was observed.ConclusionsPatients with MacTel sustain progressive inner retinal neurodegeneration similar to those with diabetes without diabetic retinopathy. Further research is needed to understand the consequences of retinal thinning in MacTel.
Details
- Title: Subtitle
- Progressive inner retinal neurodegeneration in non-proliferative macular telangiectasia type 2
- Creators
- Alec L Amram - Department of Ophthalmology & Visual Sciences, University of Iowa Health Care, Iowa City, Iowa, USAS Scott Whitmore - Department of Ophthalmology & Visual Sciences, University of Iowa Health Care, Iowa City, Iowa, USACheryl Wang - University of IowaChristine Clavell - Department of Ophthalmology & Visual Sciences, University of Iowa Health Care, Iowa City, Iowa, USALance J Lyons - Retina Consultants of TexasAlexander M Rusakevich - Retina Consultants of TexasIan Han - University of IowaJames Folk - University of IowaH Culver Boldt - University of IowaEdwin M Stone - University of IowaStephen R Russell - University of IowaKyungmoo Lee - Department of Ophthalmology & Visual Sciences, University of Iowa Health Care, Iowa City, Iowa, USAMichael Abramoff - University of Iowa, Fraternal Order of Eagles Diabetes Research CenterCharles Wykoff - Retina Consultants of TexasElliott H Sohn - Department of Ophthalmology & Visual Sciences, University of Iowa Health Care, Iowa City, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- British journal of ophthalmology, Vol.109(3), pp.401-407
- DOI
- 10.1136/bjo-2023-325115
- PMID
- 39288977
- PMCID
- PMC11866295
- NLM abbreviation
- Br J Ophthalmol
- ISSN
- 0007-1161
- eISSN
- 1468-2079
- Publisher
- BMJ Publishing Group Ltd
- Grant note
- P30EY025580 / NEI R01EY035435 / National Eye Institute (http://dx.doi.org/10.13039/100000053)
- Language
- English
- Electronic publication date
- 09/17/2024
- Date published
- 03/2025
- Academic Unit
- Electrical and Computer Engineering; The University of Iowa Institute for Vision Research; Iowa Neuroscience Institute; John and Marcia Carver Nonprofit Genetic Testing Laboratory; Fraternal Order of Eagles Diabetes Research Center; Ophthalmology and Visual Sciences
- Record Identifier
- 9984704841402771
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