Progressive morphometric and cognitive changes in vascular dementia

John Gunstad; Adam M Brickman; Robert H Paul; Jeffrey Browndyke; David J Moser; Brian R Ott; Norman Gordon; Omar Haque; Ronald A Cohen

doi:10.1016/j.acn.2004.07.001

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Progressive morphometric and cognitive changes in vascular dementia

Journal article

Open access

Peer reviewed

Progressive morphometric and cognitive changes in vascular dementia

John Gunstad, Adam M Brickman, Robert H Paul, Jeffrey Browndyke, David J Moser, Brian R Ott, Norman Gordon, Omar Haque and Ronald A Cohen

Archives of clinical neuropsychology, Vol.20(2), pp.229-241

03/2005

DOI: 10.1016/j.acn.2004.07.001

PMID: 15708732

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Abstract

Evidence for progressive cognitive decline in vascular dementia (VaD) is mixed, with some studies showing little or no decline over time. One possible explanation for these inconsistent findings is the heterogeneity of pathology encompassed by the VaD diagnosis. It is possible that subtypes of VaD (i.e. those resulting from different lesion distributions) show different patterns of cognitive decline. In the present study, a heterogeneous VaD group demonstrated cognitive decline from baseline to 12-month follow-up. Although this decline was coincident to morphometric changes (i.e. increased subcortical hyperintensities (SH), decreased whole brain volume (WBV)), no relationship emerged between cognitive decline and morphometric changes. Preliminary examination of VaD subtypes revealed patients with subcortical infarct or SH-only exhibited greater decline than VaD patients with cortical lesions. Further research is needed to determine whether this observed decline is attributable to differential lesion distribution or statistical artifact.

Severity of Illness Index

Dementia, Vascular - psychology

Dementia, Vascular - complications

Brain - anatomy & histology

Anthropometry

Humans

Dementia, Vascular - drug therapy

Nootropic Agents - therapeutic use

Male

Cerebral Infarction - complications

Cytidine Diphosphate Choline - therapeutic use

Disease Progression

Magnetic Resonance Imaging

Aged, 80 and over

Brain - pathology

Cerebral Infarction - psychology

Female

Aged

Details

Title: Subtitle: Progressive morphometric and cognitive changes in vascular dementia
Creators: John Gunstad - Department of Psychiatry and Human Behavior, Brown Medical School, Miriam Hospital, Coro West-Third Floor, 1 Hoppin St., Providence RI 02903, USA. JGunstad@Lifespan.org
Adam M Brickman
Robert H Paul
Jeffrey Browndyke
David J Moser
Brian R Ott
Norman Gordon
Omar Haque
Ronald A Cohen
Resource Type: Journal article
Publication Details: Archives of clinical neuropsychology, Vol.20(2), pp.229-241
DOI: 10.1016/j.acn.2004.07.001
PMID: 15708732
NLM abbreviation: Arch Clin Neuropsychol
ISSN: 0887-6177
eISSN: 1873-5843
Publisher: United States
Language: English
Date published: 03/2005
Academic Unit: Psychiatry; Medicine Administration
Record Identifier: 9984003920402771

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