Progressive pathology is functionally linked to the domains of language and emotion: meta-analysis of brain structure changes in schizophrenia patients

Thomas Nickl-Jockschat; Frank Schneider; Alena Pagel; Angie Laird; Peter Fox; Simon Eickhoff

doi:10.1007/s00406-011-0249-8

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Progressive pathology is functionally linked to the domains of language and emotion: meta-analysis of brain structure changes in schizophrenia patients

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Progressive pathology is functionally linked to the domains of language and emotion: meta-analysis of brain structure changes in schizophrenia patients

Thomas Nickl-Jockschat, Frank Schneider, Alena Pagel, Angie Laird, Peter Fox and Simon Eickhoff

European archives of psychiatry and clinical neuroscience, Vol.261(S2), pp.166-171

11/2011

DOI: 10.1007/s00406-011-0249-8

PMCID: PMC5324975

PMID: 21909731

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Abstract

Schizophrenia is a neuropsychiatric disorder entailing progressive psychotic, cognitive and affective symptoms. Several imaging studies identified brain structure abnormalities in schizophrenia patients, particularly in fronto-temporal regions and evidence for progressive anatomical changes. Here, we synthesised these findings by quantitative coordinate-based meta-analysis, assessing regions of consistently reported brain structure changes, their physiological functions and the correlation of their likelihood with disease duration. The meta-analysis revealed four significant clusters of convergent grey matter reduction, while one cluster indicated higher grey matter values in patients. A voxel-wise analysis revealed a correlation between grey matter reduction and disease duration in the left anterior insula. Functional characterisation revealed significant association with reward, affective processing and language functions. The current analysis allowed the identification of consistent morphometric changes across a large sample of studies in regions that are associated with neurophysiological functions that are altered as hallmarks of schizophrenia psychopathology. The observation that the location of presumably progressive pathology is functionally linked to language and emotion is well in line with increasing deficits in these domains with disease progression in schizophrenia.

Neurology

Psychiatry

Schizophrenia

Disease duration

Neurosciences

BrainMap

Medicine & Public Health

Anatomical likelihood estimation

Structure–function relationship

Brain structure

Details

Title: Subtitle: Progressive pathology is functionally linked to the domains of language and emotion: meta-analysis of brain structure changes in schizophrenia patients
Creators: Thomas Nickl-Jockschat - JARA—Translational Brain Medicine Aachen/Juelich Germany
Frank Schneider - JARA—Translational Brain Medicine Aachen/Juelich Germany
Alena Pagel - Department of Psychiatry, Psychotherapy and Psychosomatics RWTH Aachen University Pauwelsstrasse 30, D-52074 Aachen Germany
Angie Laird - Research Imaging Institute University of Texas Health Science Center San Antonio TX USA
Peter Fox - Research Imaging Institute University of Texas Health Science Center San Antonio TX USA
Simon Eickhoff - Institute of Neuroscience and Medicine-2, Forschungszentrum Jülich GmbH Juelich Germany
Resource Type: Journal article
Publication Details: European archives of psychiatry and clinical neuroscience, Vol.261(S2), pp.166-171
DOI: 10.1007/s00406-011-0249-8
PMID: 21909731
PMCID: PMC5324975
NLM abbreviation: Eur Arch Psychiatry Clin Neurosci
ISSN: 0940-1334
eISSN: 1433-8491
Publisher: Springer-Verlag; Berlin/Heidelberg
Language: English
Date published: 11/2011
Academic Unit: Psychiatry; Neuroscience and Pharmacology
Record Identifier: 9984003439402771

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